Anti-Human PDCD1 Recombinant Antibody (PD1-17) (CAT#: TAB-0961CL)

This antibody can inhibit binding of PD-L1 to PD-1 and modulate immune responses mediated by TcR and CD28, in particular. It may be used in treating autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, and other immune system disorders.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 Reactivity of IgG-converted antibodies with human or mouse PD-1 as determined by ELISA.

Figure 1 Reactivity of IgG-converted antibodies with human or mouse PD-1 as determined by ELISA.

ELISA

Figure 2 An ELISA demonstrating that selected PD-1 antibodies inhibit binding of PD-L1 to PD-1.

Figure 2 An ELISA demonstrating that selected PD-1 antibodies inhibit binding of PD-L1 to PD-1.

FuncS

Figure 3 T-cell proliferation assays demonstrating that co-engagement by TcR and anti-PD-1 antibody PD1-17 or PD-L1.

Figure 3 T-cell proliferation assays demonstrating that co-engagement by TcR and anti-PD-1 antibody PD1-17 or PD-L1.

Fc reduces proliferation. Co-engagement by TcR and anti-PD-1 J110 has no effect on proliferation.

FuncS

Figure 4 Enhanced proliferation of primary T cells by PD1-17 in a soluble form.

Figure 4 Enhanced proliferation of primary T cells by PD1-17 in a soluble form.


Specifications

  • Immunogen
  • Soluble PD-1 fusion protein
  • Host Species
  • Human
  • Derivation
  • scFv phagemid library
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • PD1-17
  • Applications
  • ELISA, FuncS
  • Related Disease
  • Rheumatoid arthritis (RA)

Applications

  • Application Notes
  • The antibody was validated for ELISA, Functional Assay. For details, refer to Published Data.

Target

  • Alternative Names
  • PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-900 Afuco™ Anti-PDCD1 ADCC Recombinant Antibody (Pidilizumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-028ML Afuco™ Anti-PDCD1 ADCC Recombinant Antibody (Gilvetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-012ML Afuco™ Anti-PDCD1 ADCC Recombinant Antibody (Camrelizumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, BL ADCC enhanced antibody
AFC-TAB-770 Afuco™ Anti-PDCD1 ADCC Recombinant Antibody (Nivolumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-H55 Afuco™ Human Anti-PDCD1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H55) FuncS, IF, Neut, ELISA, FC IgG1, κ

Single-domain Antibody

CAT Product Name Application Type
HPAB-N0309-YC-VHH Recombinant Humanized Anti-PDCD1 Single Domain Antibody (NOV011YC) FC, ELISA Humanized VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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