Anti-Human PDGFRB Therapeutical Antibody (IMC-2C5) (CAT#: TAB-706CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human PDGFRB. IMC-2C5 binds to both human and mouse PDGFRβ. And it is involved in the treatment of a broad range of human cancers.
Specific Inquiry
Inhib
Figure 1 IMC-2C5 antibody inhibits tumor growth as a monotherapy agent in xenograft models.
Shen, J., Vil, M. D., Prewett, M., Damoci, C., Zhang, H., Li, H., ... & Bassi, R. (2009). Development of a fully human anti-PDGFRβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody. Neoplasia (New York, NY), 11(6), 594.
FuncS
Figure 2 IMC-2C5 enhances the antitumor activity of an anti-VEGFR2 antibody, DC101.
Athymic nude mice bearing xenografted tumors of 200 to 300 mm size were randomized and divided into four treatment groups (n = 12 per group) and were treated by i.p. injections three times a week with USP saline, IMC-2C5 (40 mg/kg), DC101 (40 mg/kg), or IMC-2C5 plus DC101 (40 mg/kg each).
Shen, J., Vil, M. D., Prewett, M., Damoci, C., Zhang, H., Li, H., ... & Bassi, R. (2009). Development of a fully human anti-PDGFRβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody. Neoplasia (New York, NY), 11(6), 594.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- Inhib, FuncS
- Related Disease
- Solid Tumors
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- Short Term Storage: 4°C
Long Term Storage: -20°C
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay and Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "PDGFRB"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1734z | Mouse Anti-PDGFRB Recombinant Antibody (clone 1H11) | ELISA, IF, WB | Mouse IgG1 |
| HPAB-0281CQ | Human Anti-PDGFRB Recombinant Antibody (clone 1B3) | ELISA, FC, WB, Neut | Human IgG |
| MRO-2112-CN | Rabbit Anti-PDGFRB Polyclonal Antibody (MRO-2112-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-N0227-YC | Human Anti-PDGFRB Recombinant Antibody (clone PFH2) | Block | Human IgG |
| VS3-CJ543 | Rabbit Anti-PDGFRB Recombinant Antibody (VS3-CJ543) | WB, IHC, IP | Rabbit IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0988CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0988CL) | ELISA | Human IgG |
| TAB-0989CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0989CL) | ELISA | Human IgG |
| TAB-0990CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0990CL) | ELISA | Human IgG |
| TAB-0991CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0991CL) | ELISA | Human IgG |
| TAB-0988CL-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (TAB-0988CL-S(P)) | ELISA | Human scFv |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1850CQ | Recombinant Rat Anti-Pdgfrb Antibody (APB5) | FC, FuncS, Neut | IgG2a, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2638 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (DS2638AB) | WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-141CQ | Human Anti-Pdgfrb Antibody Fab Fragment (1B3) | FC, WB, Neut | Human Fab |
| HPAB-N0227-YC-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone PFH2); Fab Fragment | Block | Human Fab |
| HPAB-1110-CN-F(E) | Mouse Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1110-CN-F(E)) | ELISA | Mouse Fab |
| HPAB-1111-CN-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1111-CN-F(E)) | ELISA | Human Fab |
| HPAB-1112-CN-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1112-CN-F(E)) | ELISA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-448CQ | Afuco™ Anti-PDGFRB Recombinant Antibody (AFC-TAB-448CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | Human IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0227-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone PFH2); scFv Fragment | Block | Human scFv |
| HPAB-S0105-YC-S(P) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-S0106-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11); scFv Fragment | ELISA, Neut | Humanized scFv |
| HPAB-S0107-YC-S(P) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-S0108-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.22); scFv Fragment | ELISA, Neut | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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