Anti-Human PERP Recombinant Antibody (KM3481) (CAT#: TAB-1018CL)

Figure 1 Reactivity of purified anti-PERP chimeric antibody KM3481 to PERP/CHO cells using flow cytometry.

The ordinate and the abscissa show mean fluorescence intensity and an antibody concentration, respectively.

Figure 2 Reactivity of anti-PERP chimeric antibody KM3481 to each cancer cell line using flow cytometry.

The ordinate and the abscissa show cell numbers and fluorescence intensity, respectively.

Figure 3 CDC activity of anti-PERP chimeric antibody KM3481 to PERP/CHO cells.

The ordinate and the abscissa show cytotoxic activity (%) and an antibody concentration, respectively.

Figure 4 ADCC activity of anti-PERP chimeric antibody KM3481 to each cell line.

The ordinate and the abscissa show cytotoxic activity (%) and an antibody concentration, respectively.

Figure 5 Changes with lapse of days for a mean value of tumor volumes in an administered group when anti-PEAP chimeric antibody KM3481 was administered to a mouse to which lung cancer cell line PC-9 was intradermally transplanted.

The abscissa and the ordinate show days after transplantation of tumor and the tumor volume, respectively. In the drawing, x shows a group to which no antibody was administered; ○ shows a group to which 0.1 mg/kg of anti-PERP chimeric antibody KM3481 was administered; □ shows a group to which 1 mg/kg of anti-PERP chimeric antibody KM3481 was administered; and ▲ shows a group to which 10 mg/kg of anti-PERP chimeric antibody KM3481 was administered. Bar shows a standard deviation.