Products

Anti-PREV Intrabody [Tat] (IAB-B007(T))

Recombinant anti-PREV intrabody in fusion with HIV Tat works within cells to bind secifically to a retrovirus protein PREV particle protein, expressed in 293T cells. Intracellular antibody which disrupts the catalysis of the production of the xenoantigen galactose α 1,3 galactose and/or a polynucleotide construct which encodes an intracellular antibody which binds specifically to a retrovirus protein, such as a PERV particle protein.      

Specifications
Immunogen
porcine retroviruses
Host
llama
Type
vhh-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
PERV
Applications
Products can be used for: Protein fragment complementation; Neutralization; Functional studies
Target
Alternative Names
PREV; porcine retroviruses

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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