Anti-Human PRG3 Recombinant Antibody (4F12) (CAT#: TAB-1062CL)
This antibody is capable of binding to the PRG-3 protein as well as inhibiting the growth of cells expressing the PRG-3 protein. The growth inhibitory activity is cytotoxic activity, such as antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.
Specific Inquiry
FC
Figure 1 The reactivity of a PRG-3 hybridoma culture supernatant to PRG-3/293T-REX cells.
The reactivity of the antibody contained in the hybridoma culture supernatant toward PRG3+/293 cells wherein the expression of PRG-3 was induced and PRG3-/293 cells wherein the expression of PRG-3 was not induced was compared by GeoMean values measured by flow cytometry.
FC
Figure 2 The binding of the anti-PRG-3 monoclonal antibody to HepG2 cells.
The binding of the antibody to HepG2 cells at antibody concentrations of 10 μg/mL, 1 μg/mL, and 0.1 μg/mL was compared by GeoMean values measured by flow cytometry;
ADCC
Figure 3 ADCC activity of the anti-PRG-3 antibody in the OF5-G8 cell line.
CDC
Figure 4 CDC activity of the anti-PRG-3 antibody in the OF5 cell line.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 4F12
- Applications
- FC, ADCC, CDC
- Related Disease
- Hepatocellular carcinoma, lung cancer, colon cancer, and glioblastoma
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry, Antibody-dependent Cellular Cytotoxicity Assay and Complement-dependent Cytotoxicity Assay.
Target
- Alternative Names
- PRG3; proteoglycan 3; MBP2; MBPH; prepro-MBPH; prepro-major basic protein homolog; eosinophil major basic protein homolog
- Gene ID
- 10394
- UniProt ID
- Q9Y2Y8
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Mouse Antibody
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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