Products

Anti-PS Immunocytokine, IgG (2aG4)-IL2 (ACFP-SH006)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PS IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PS as well as the biological activity of IL2. 2aG4-IL2 has great improvement than 2aG4 and IL2 alone. First, the improvement is antigen-specific indicating that 2aG4-IL2 blocks PS-dependent immunosuppressive signals. Second, the improvement is greater with 2aG4-IL2 than with 2aG4 alone, indicating that immunostimulatory cytokine-IL2 contributes to the vaccination. This immunocytokine was designed for treating PS-expressing tumor.      

Specifications
Target
PS
Molecule Class
IgG-IL2
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
2aG4
Related Disease
PS-expressing tumor
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Mouse
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
Phosphatidyl Serine; Phosphatidylserine; Ptd-L-Ser; PS

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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