Human Anti-PS Recombinant Antibody (clone pSTAb) (CAT#: PABZ-170)
Recombinant Human Antibody (pSTAb) is capable of binding to PS (pThr peptide), expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-PS (pThr peptide) mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-PS (pThr peptide) proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. PSTAb with sequence "STPRGST".
Specific Inquiry
Figure 1 Affinity measurements of mAb scaffolds as determined by Biacore
Koerber, J. T., Thomsen, N. D., Hannigan, B. T., Degrado, W. F., & Wells, J. A. (2013). Nature-inspired design of motif-specific antibody scaffolds. Nature biotechnology, 31(10), 916.
Figure 2 Selection and characterization of pSer-, pSer/pThr- and pTyr-specific scaffolds. Competition ELISAs were used to determine the specificity of each mAb scaffold (n = 3, error bars represent s.d.).
(a,b) For both pSAb (a) and pSTAb (b), no binding inhibition was observed for the unphosphorylated peptides up to 2 µM, whereas strong inhibition was observed for the phosphorylated peptides. (c) For pYAb, weak inhibition was observed at high concentrations of the unphosphorylated Tyr peptide, but ~20-fold less pTyr peptide was required to observe the same level of inhibition.
Koerber, J. T., Thomsen, N. D., Hannigan, B. T., Degrado, W. F., & Wells, J. A. (2013). Nature-inspired design of motif-specific antibody scaffolds. Nature biotechnology, 31(10), 916.
Specifications
- Immunogen
- phospho-specific
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Tested positive against synthetic PS (pThr peptide)
- Clone
- pSTAb
- Applications
- ELISA, WB
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- PS; phospho-specific
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-819-S(P) | Recombinant Anti-PS Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-819-S(P) | Recombinant Human Anti-PS Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| PFBZ-170 | Human Anti-PS Recombinant Antibody (clone pSTAb); Fab Fragment | ELISA, WB | Humanized Fab |
| PFBZ-172 | Human Anti-PS Recombinant Antibody (clone pSAb); Fab Fragment | ELISA, WB | Humanized Fab |
| PFBZ-173 | Human Anti-PS Recombinant Antibody (clone pYAb); Fab Fragment | ELISA, WB | Humanized Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-819 | Recombinant Human Anti-PS Antibody | WB, IP, FuncS | IgG |
| PABZ-172 | Human Anti-PS Recombinant Antibody (clone pSAb) | ELISA, WB | Humanized IgG |
| PABZ-173 | Human Anti-PS Recombinant Antibody (clone pYAb) | ELISA, WB | Humanized IgG |
| FAMAB-0255YC | Mouse Anti-PS Recombinant Antibody (clone PS4A7) | ELISA | Mouse IgG |
| HPAB-1899-FY | Mouse Anti-PS Recombinant Antibody (HPAB-1899-FY) | Inhib, FuncS, ELISA, WB, IF | Mouse IgG3, κ |
Mouse Antibody
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0255-YC-F(E) | Mouse Anti-PS Recombinant Antibody (clone PS4A7); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0256-YC-F(E) | Mouse Anti-PS Recombinant Antibody (clone PS3A); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0257-YC-F(E) | Mouse Anti-PS Recombinant Antibody (clone PSC8); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1899-FY-S(P) | Mouse Anti-PS Recombinant Antibody; scFv Fragment (HPAB-1899-FY-S(P)) | ELISA, Inhib | Mouse scFv |
| FAMAB-0104JF-F(E) | Mouse Anti-PS Recombinant Antibody (clone 78.2); Fab Fragment | DB, FELISA, ELISA, FuncS | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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