Products

Anti-PSMA Immunocytokine, IgG (2C9)-IL2 (ACFP-SH007)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PSMA IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PSMA as well as the biological activity of IL2. This antibody-cytokine fusion protein is an C-terminus interleukin-2 (IL2)-fused immunocytokine, exhibited enhanced cytotoxic activity against PSMA-expressing prostate cancer cells in the presence of PBMCs. It has a therapeutic potential for prostate cancer by stimulating lymphocyte-mediated antitumor cytotoxicity. This immunocytokine was designed for treating prostate cancer.      

Specifications
Target
PSMA
Molecule Class
IgG1-IL2
Species Reactivity
Human
Host
Chimeric (Mouse-Human)
Expression Host
CHO
Clone
2C9
Related Disease
prostate cancer
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP
Entrez Gene ID
2346
UniProt ID
Q04609

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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