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Recombinant Anti-mouse PTEN Intrabody [(D-Arg)9] (CAT#: IAB-B021(A))

Recombinant anti-PTEN intrabody linked to (D-Arg)9 works within cells and directs against PTEN in T cells, expressed in CHO cells. The intrabody can modulate the expression and/or activity of PTEN in T cells, regulatory T cells, and CD4 T cells.


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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/if_selected.jpg
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/134179_A_5_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_B_8_5.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171862-PTEN/subcellular

Specifications

  • Immunogen
  • mouse phosphatase and tensin homolog
  • Host Species
  • human
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • mouse
  • Applications
  • Antibody assay: Protein fragment complementation; Western blot; Functional studies

Product Property

  • Purity
  • Purity>95% by SDS-PAGE
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Target

  • Alternative Names
  • PTEN; phosphatase and tensin homolog; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; mitochondrial PTENalpha; mutated in multiple ad

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "PTEN"

Recombinant Antibody

CAT Product Name Application Type
MOB-1640z Mouse Anti-PTEN Recombinant Antibody (clone 27C11) WB, ELISA, FC, ICC, IF Mouse IgG1
MOB-0338MZ Recombinant Mouse Anti-Human PTEN Antibody (clone 7I3.2) IHC Mouse antibody
MRO-1293-CN Recombinant Rabbit Anti-PTEN Monoclonal Antibody (CBACN-466) WB, IF, IHC Rabbit IgG
MOB-0231F Mouse Anti-PTEN Recombinant Antibody (clone 2C10) IHC-P, IF Mouse IgG
VS3-XY1314 Mouse Anti-PTEN Recombinant Antibody (clone 4D8) WB, IP, IF Mouse IgG1

Intrabody

CAT Product Name Application Type
IAB-B021(G) Recombinant Anti-mouse PTEN Intrabody [+36 GFP] FACS, ELISA, IF, FuncS scFv-(+36GFP)
IAB-B021(T) Recombinant Anti-mouse PTEN Intrabody [Tat] FACS, ICC, FuncS scFv-Tat

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2915 Hi-Affi™ Recombinant Rabbit Anti-PTEN Monoclonal Antibody (DS2915AB) ICC, IHC-P, IP, WB IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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