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Anti-PTEN Intrabody [(D-Arg)9] (IAB-B021(A))

Recombinant anti-PTEN intrabody linked to (D-Arg)9 works within cells and directs against PTEN in T cells, expressed in CHO cells. The intrabody can modulate the expression and/or activity of PTEN in T cells, regulatory T cells, and CD4 T cells.      

Specifications
Immunogen
mouse phosphatase and tensin homolog
Host
human
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
mouse
Applications
Antibody assay: Protein fragment complementation; Western blot; Functional studies
Target
Alternative Names
PTEN; phosphatase and tensin homolog; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik
Entrez Gene ID
19211
UniProt ID
O08586

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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