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Recombinant Anti-mouse PTEN Intrabody [Tat] (CAT#: IAB-B021(T))

Recombinant anti-PTEN intrabody in fusion with HIV Tat works within cells and is directed against PTEN in T cells, expressed in CHO cells. The intrabody can modulate the expression and/or activity of PTEN in T cells, regulatory T cells, and CD4 T cells.


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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/if_selected.jpg
Figure 2 IHC staining of human testis
Figure 2 IHC staining of human testis
(Immunohistochemical staining of human testis shows cytoplasmic positivity in cells in seminiferous ducts.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31335/134179_A_5_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_B_8_5.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4076/12125_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171862-PTEN/subcellular

Specifications

  • Immunogen
  • mouse phosphatase and tensin homolog
  • Host Species
  • human
  • Type
  • scFv-Tat
  • Cell Penetrating Peptide
  • TAT
    TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
  • Species Reactivity
  • mouse
  • Applications
  • Products can be used for: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies

Product Property

  • Purity
  • >95%, by SDS-PAGE, under reducing conditions
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Target

  • Alternative Names
  • PTEN; phosphatase and tensin homolog; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; mitochondrial PTENalpha; mutated in multiple ad

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "PTEN"

Recombinant Antibody

CAT Product Name Application Type
MOB-1640z Mouse Anti-PTEN Recombinant Antibody (clone 27C11) WB, ELISA, FC, ICC, IF Mouse IgG1
MOB-0338MZ Recombinant Mouse Anti-Human PTEN Antibody (clone 7I3.2) IHC Mouse antibody
ZG-0527U Rabbit Anti-Phospho-PTEN (S380) Recombinant Antibody (clone 4D10) ELISA, WB Rabbit IgG
VS3-QX925 Mouse Anti-PTEN Recombinant Antibody (clone 4G4-4H9-1E10) IHC Mouse IgG1
VS3-QX926 Mouse Anti-PTEN Recombinant Antibody (clone 7H2-6G9-6H5) IHC Mouse IgG1

Intrabody

CAT Product Name Application Type
IAB-B021(A) Recombinant Anti-mouse PTEN Intrabody [(D-Arg)9] PCA, WB, FuncS scFv-(D-Arg)9
IAB-B021(G) Recombinant Anti-mouse PTEN Intrabody [+36 GFP] FACS, ELISA, IF, FuncS scFv-(+36GFP)

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2915 Hi-Affi™ Recombinant Rabbit Anti-PTEN Monoclonal Antibody (DS2915AB) ICC, IHC-P, IP, WB IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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