Products

Anti-PTEN Intrabody [Tat] (IAB-B021(T))

Recombinant anti-PTEN intrabody in fusion with HIV Tat works within cells and is directed against PTEN in T cells, expressed in CHO cells. The intrabody can modulate the expression and/or activity of PTEN in T cells, regulatory T cells, and CD4 T cells.      

Specifications
Immunogen
mouse phosphatase and tensin homolog
Host
human
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
mouse
Applications
Products can be used for: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies
Target
Alternative Names
PTEN; phosphatase and tensin homolog; TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik
Entrez Gene ID
19211
UniProt ID
O08586

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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