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Anti-RAS Intrabody [Tat] (IAB-B009(T))

Recombinant anti-RAS intrabody in fusion with HIV Tat works within cells to bind human RAS, expressed in E. coli cells. An intracellular antibody constructed by the single chain antibody can inhibit proliferations and invasion abilities of the human tumor cells with highly expressed p21ras proteins.      

Specifications
Immunogen
human Kirsten rat sarcoma viral oncogene homolog
Host
human
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
human
Applications
Antibody assay: Flow Cytometry; Immunofluorescence; Functional studies
Target
Alternative Names
KRAS; Kirsten rat sarcoma viral oncogene homolog; NS; NS3; CFC2; KRAS1; KRAS2; RASK2
Entrez Gene ID
3845
UniProt ID
A0A024RAV5

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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