Anti-ROS-CII Antibody-Cytokine Fusion Protein, scFv (1-11E)-IL10 (CAT#: ACFP-SH004)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-ROS-CII scFv to IL10. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the ROS-CII as well as the biological activity of IL10. Viral interleukin-10 (vIL10) was fused to anti-ROS-CII scFv (1-11E) with a matrix-metalloproteinase (MMP) cleavable linker to create 1-11E/vIL10 fusion, 1-11E/vIL10 bound specifically to ROS-CII and to damaged arthritic cartilage. This immunocytokine was designed for treating arthritic joints.


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Specifications

  • Target
  • ROS-CII
  • Molecule Class
  • scFv-IL10
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • 1-11E
  • Related Disease
  • arthritic joints
  • Cytokine 1
  • IL10
  • Cytokines 1 Description
  • Viral interleukin-10 has now been termed viral interleukin 10 (vlL-10) to reflect its protein sequence homology to "cellular" IL10 (cIL10, either murine or human IL10). It is now widely accepted that vlL-10 shares many functions with clL-10, principally, the ability to enhance survival of newly infected B cells and to diminish the production of IFN-β and IL-2 during ongoing immune reactions.
  • Cytokine 1 Species
  • Viral
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • ROS-Collagen II; ROS-CII; ROS-type II collagen

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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