Recombinant Mouse Antibody (6C2) is capable of binding to Ricin, expressed in Chinese Hamster Ovary cells (CHO).
Figure 1 Validation of the RTA-6C2 Fab interface.
A, binding ability of 6C2 with RTA and RTA mutants are measured by ELISA. B, inhibition of RTA and RTA mutants enzymatic activities by 6C2. After RTA or RTA mutants were preincubated with (or without) 6C2 antibody, luciferase template mRNA was added to the rabbit reticulocyte lysates containing intact ribosomes. The relative luciferase activity, which was linear with the concentration of luciferase, was measured by GloMaxTM 96 Microplate Luminometer. C, table showing the RTA mutants.
Zhu, Y., Dai, J., Zhang, T., Li, X., Fang, P., Wang, H.,... & Guo, Y. (2013). Structural insights into the neutralization mechanism of monoclonal antibody 6C2 against ricin. Journal of Biological Chemistry, 288(35), 25165-25172.
Figure 2 SPR analysis of ribosome binding to RTA in the presence (A) and absence of the antibody 6C2 (B).
Zhu, Y., Dai, J., Zhang, T., Li, X., Fang, P., Wang, H.,... & Guo, Y. (2013). Structural insights into the neutralization mechanism of monoclonal antibody 6C2 against ricin. Journal of Biological Chemistry, 288(35), 25165-25172.
Figure 3 Pulldown analysis of ribosome binding to RTA in the presence and absence of the antibody 6C2.
Zhu, Y., Dai, J., Zhang, T., Li, X., Fang, P., Wang, H.,... & Guo, Y. (2013). Structural insights into the neutralization mechanism of monoclonal antibody 6C2 against ricin. Journal of Biological Chemistry, 288(35), 25165-25172.
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CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-318 | Recombinant Mouse Anti-Ricin Antibody scFv Fragment (6C2) | Neut, FuncS | scFv |
PSBL-685 | Mouse Anti-Ricin Recombinant Antibody (clone mAb RAC18); scFv Fragment | Neut | Mouse scFv |
FAMAB-0310JF-S(P) | Mouse Anti-Ricin Recombinant Antibody (clone 3E1); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
PSBS-0050 | Mouse Anti-Ricin Recombinant Antibody; scFv Fragment (PSBS-0050) | ELISA, Neut, FuncS | Mouse scFv |
PSBS-0068 | Human Anti-Ricin Recombinant Antibody; scFv Fragment (PSBS-0068) | ELISA, Neut, FuncS | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABZ-192 | Mouse Anti-Ricin Recombinant Antibody (clone RAC18) | Neut | Mouse IgG |
PABL-692 | Mouse Anti-Ricin Recombinant Antibody (clone mAb RAC18) | Neut | Mouse IgG |
FAMAB-0060JF | Monkey Anti-Ricin Recombinant Antibody (clone 43RCA) | WB, ELISA, IHC, Neut | Monkey IgG |
FAMAB-0310JF | Mouse Anti-Ricin Recombinant Antibody (clone 3E1) | WB, ELISA, IHC | Mouse IgG |
FAMAB-0311WJ | Camelid Anti-Ricin Recombinant Antibody (clone LRE7) | ELISA, Neut | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-192 | Mouse Anti-Ricin Recombinant Antibody (clone RAC18); scFv Fragment | Neut | Mouse scFv |
HPAB-1607-FY-S(P) | Human Anti-Ricin Recombinant Antibody (clone REV8); Fab Fragment | WB, ELISA, IP | Chimeric (macaque/human) Fab |
HPAB-1608-FY-S(P) | Human Anti-Ricin Recombinant Antibody (clone REV7); Fab Fragment | WB, ELISA, IP | Chimeric (human/macaque) Fab |
FAMAB-0060JF-F(E) | Monkey Anti-Ricin Recombinant Antibody (clone 43RCA); Fab Fragment | WB, ELISA, FuncS | Monkey Fab |
PFBS-0050 | Mouse Anti-Ricin Recombinant Antibody; Fab Fragment (PFBS-0050) | ELISA, Neut, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-165 | Recombinant Mouse Anti-Ricin Antibody (RAC18) | FuncS, IF | IgG |
PABX-165-S (P) | Recombinant Mouse Anti-Ricin Antibody scFv Fragment (RAC18) | Neut, FuncS | scFv |
PABX-165-F (E) | Recombinant Mouse Anti-Ricin Antibody Fab Fragment (RAC18) | Neut, FuncS | Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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