Anti-S. aureus antibody is a Human antibody of IgG class that binds to an S. aureus. It developed From a human scFv phage library.
Figure 1 Blocking activity of antibodies against α-hemolysin in human serum samples and in vitro neutralizing activity of LTM14.
Foletti, D., Strop, P., Shaughnessy, L., Hasa-Moreno, A., Casas, M. G., Russell, M., ... & Pons, J. (2013). Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. Journal of molecular biology, 425(10), 1641-1654.
Figure 2 LTM14 dose-dependently blocks the lytic activity of α-hemolysin on REs.
Foletti, D., Strop, P., Shaughnessy, L., Hasa-Moreno, A., Casas, M. G., Russell, M., ... & Pons, J. (2013). Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. Journal of molecular biology, 425(10), 1641-1654.
Figure 3 In vivo efficacy of LTM14 in a mouse model of S. aureus pneumonia, prophylactic antibody administration.
Survival curves for groups of mice dosed with LTM14 (30 mg/kg ip) or vehicle before intranasal challenge with 3.2 x 10⁸ CFU of S. aureus USA300 LAC.
Foletti, D., Strop, P., Shaughnessy, L., Hasa-Moreno, A., Casas, M. G., Russell, M., ... & Pons, J. (2013). Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. Journal of molecular biology, 425(10), 1641-1654.
Figure 4 In vivo efficacy of LTM14 in a mouse model of S. aureus pneumonia, therapeutic antibody administration and combination with linezolid.
Survival curves for groups of mice dosed with either 30 mg/kg LTM14 or 12 mg/kg linezolid 12 and 18 h after intranasal challenge with 5x 10⁸ CFU of S. aureus USA300 LAC.
Foletti, D., Strop, P., Shaughnessy, L., Hasa-Moreno, A., Casas, M. G., Russell, M., ... & Pons, J. (2013). Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin. Journal of molecular biology, 425(10), 1641-1654.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-870 | Recombinant Anti-S. aureus Antibody | WB, IP, FuncS | IgG |
PABL-328 | Recombinant Human Anti-S. aureus Antibody (4497) | WB, ELISA, FuncS | IgG |
HPAB-0920-FY | Recombinant Anti-S. aureus Antibody (5.11.H10) | E | |
HPAB-0921-FY | Recombinant Anti-S. aureus Antibody (5.27.A11) | E | |
HPAB-0922-FY | Recombinant Anti-S. aureus Antibody (5.6.H9) | E |
CAT | Product Name | Application | Type |
---|---|---|---|
NABL-033 | Recombinant Anti-S. aureus VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-058MZ-F(E) | Human Anti-S. aureus Recombinant Antibody; Fab Fragment (MRO-058MZ-F(E)) | ELISA | Human Fab |
MRO-059MZ-F(E) | Human Anti-S. aureus Recombinant Antibody; Fab Fragment (MRO-059MZ-F(E)) | ELISA | Human Fab |
MRO-060MZ-F(E) | Human Anti-S. aureus Recombinant Antibody; Fab Fragment (MRO-060MZ-F(E)) | ELISA | Human Fab |
MRO-061MZ-F(E) | Human Anti-S. aureus Recombinant Antibody; Fab Fragment (MRO-061MZ-F(E)) | ELISA | Human Fab |
PABX-167-F (E) | Recombinant Human Anti-S. aureus Antibody Fab Fragment (LTM14) | Neut, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-167-S (P) | Recombinant Human Anti-S. aureus Antibody scFv Fragment (LTM14) | Neut, ELISA, FuncS | scFv |
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