Recombinant Anti-human SGK1 Intrabody [(D-Arg)9] (CAT#: IAB-B057(A))

Recombinant anti-SGK1 intrabody linked to (D-Arg)9 works within cells to inhibit the activity of human SGK1, expressed in 293T cells. The anti-Sgk intrabodies recognize the enzymatically active form of Sgk and which, upon binding, inhibit Sgk's ability to transphosphorylate.


Specific Inquiry
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  • Purity:
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • human serum/glucocorticoid regulated kinase 1
  • Host Species
  • human
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • human
  • Applications
  • Products can be used for: Western blot; Neutralization; Functional studies

Product Property

  • Purity
  • >97%, by SDS-PAGE under reducing conditions
  • Storage
  • Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • SGK1; serum/glucocorticoid regulated kinase 1; SGK; serine/threonine-protein kinase Sgk1; Sgk1 variant i3; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "SGK1"

Intrabody

CAT Product Name Application Type
IAB-B057(G) Recombinant Anti-human SGK1 Intrabody [+36 GFP] WB, ICC, Neut, FuncS scFv-(+36GFP)
IAB-B057(T) Recombinant Anti-human SGK1 Intrabody [Tat] PCA, Neut, FuncS scFv-Tat

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0530MZ Chicken Anti-SGK (ab1) Polyclonal IgY WB Chicken antibody
BRD-0531MZ Chicken Anti-SGK (ab2) Polyclonal IgY WB Chicken antibody
BRD-0761MZ Chicken Anti-SGK1 Polyclonal IgY ELISA, IHC, IP, WB Chicken antibody
BRD-1049MZ Chicken Anti-SGK1 Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3249 Hi-Affi™ Recombinant Rabbit Anti-SGK1 Monoclonal Antibody (DS3249AB) WB, FC, IP, IHC IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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