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  • Recombinant Anti-human SMAD7 Intrabody [+36 GFP]

Recombinant Anti-human SMAD7 Intrabody [+36 GFP] (CAT#: IAB-B025(G))

Recombinant anti-SMAD7 intrabody in fusion with +36GFP works within cells to bind SMAD7, expressed in CHO cells. The intrabody relates to inhibito Smad7 expression or function for the preparation of a pharmaceutical composition for the prevention, amelioration or treatment of a disease of the central nervous system and/or diseases related and/or caused by said disease of the central nervous system.


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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nucleoli fibrillar center, cytosol & centrosome.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28897/281_D12_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lung
Figure 2 IHC staining of human lung
(Immunohistochemical staining of human lung shows moderate nuclear positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28897/ihc_selected.jpg
Figure 3 IHC staining of human urinary bladder
Figure 3 IHC staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows moderate nuclear positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/ihc_selected.jpg
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_B_8_5.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_9_3.jpg
Figure 6 Liver
Figure 6 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_7_4.jpg
Figure 7 Kidney
Figure 7 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_A_8_5.jpg
Figure 8 Skin
Figure 8 Skin
(Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Keratinocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Langerhans Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26212/54804_B_9_1.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000101665-SMAD7

Specifications

  • Immunogen
  • human SMAD family member 7
  • Host Species
  • llama
  • Type
  • vhh-(+36GFP)
  • Cell Penetrating Peptide
  • +36 GFP
    GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
  • Species Reactivity
  • human
  • Applications
  • Antibody assay: Enzyme-linked Immunosorbent Assay; Immunocytochemistry; Functional studies

Product Property

  • Purity
  • >97%, by SDS-PAGE under reducing conditions
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Target

  • Alternative Names
  • SMAD7; SMAD family member 7; CRCS3; MADH7; MADH8; mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8; mothers against DPP homolog 8; SMAD, mothers against DPP homolog 7; Mothers against decapentaplegic, drosophila, homolog of, 7; MAD (mother

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "SMAD7"

Recombinant Antibody

CAT Product Name Application Type
MOB-4083z Mouse Anti-SMAD7 Recombinant Antibody (clone 21B4) WB, IP, IF, ELISA Mouse IgG1, κ
MOB-1117CT Recombinant Mouse anti-Human SMAD7 Monoclonal antibody (EML551) IHC-P, WB
VS3-XY1437 Mouse Anti-SMAD7 Recombinant Antibody (clone 3E3) WB, IHC

Intrabody

CAT Product Name Application Type
IAB-B025(A) Recombinant Anti-human SMAD7 Intrabody [(D-Arg)9] FACS, ICC, FuncS vhh-(D-Arg)9
IAB-B025(T) Recombinant Anti-human SMAD7 Intrabody [Tat] PCA, Neut, FuncS vhh-Tat

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3325 Hi-Affi™ Recombinant Rabbit Anti-SMAD7 Monoclonal Antibody (DS3325AB) WB IgG
MOR-4761 Hi-Affi™ Recombinant Rabbit Anti-SMAD7 Monoclonal Antibody (TH275DS) WB, IF, ICC, FC IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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