Recombinant Anti-human SNCA Intrabody [+36 GFP] (CAT#: IAB-B031(G))

Recombinant anti-SNCA intrabody in fusion with +36GFP works within cells to bind human monomeric wild-type SNCA, expressed in E. coli cells. The intrabody stabilizes detergent-soluble monomeric syn and inhibits the formation of detergent-insoluble high-molecular-weight syn species. In addition, the intrabody ameliorates the decreased cell adhesion that characterizes the syn-overexpressing cells. Anti-SNCA intrabodies may represent novel molecular therapeutics for synucleinopathies, with implications for other neurodegenerative disorders caused by misfolded accumulated proteins.


Specific Inquiry
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  • Purity:
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • human synuclein, alpha (non A4 component of amyloid precursor)
  • Host Species
  • human
  • Type
  • scFv-(+36GFP)
  • Cell Penetrating Peptide
  • +36 GFP
    GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
  • Species Reactivity
  • human
  • Applications
  • Used for immunoassay techniques such as: Coimmunopricipation; Functional studies

Product Property

  • Purity
  • >95% (SDS-PAGE)
  • Storage
  • Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.

Target

  • Alternative Names
  • SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "SNCA"

Recombinant Antibody

Intrabody

CAT Product Name Application Type
IAB-B031(A) Recombinant Anti-human SNCA Intrabody [(D-Arg)9] FC, IF, FuncS scFv-(D-Arg)9
IAB-B031(T) Recombinant Anti-human SNCA Intrabody [Tat] ELISA, IF, Neut, FuncS scFv-Tat

Single-domain Antibody

CAT Product Name Application Type
PNBL-086 Recombinant Anti-SNCA VHH Single Domain Antibody (NbSyn2) WB, FuncS Llama VHH

Blocking Antibody

CAT Product Name Application Type
NEUT-1977CQ Recombinant Human Anti-SNCA Antibody (NAC32) IHC, WB, BL IgG1, κ

Neuroscience Antibody

CAT Product Name Application Type
NS-005CN Mouse Anti-SNCA Recombinant Antibody (NS-005CN) WB, ELISA, FC Mouse IgG2a
NS-088CN Mouse Anti-SNCA Recombinant Antibody (NS-088CN) WB, ELISA, IHC Mouse IgG2a

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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