Products

Anti-TAG72 Immunocytokine, scFv (cc49)-FasL (ACFP-SH018)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAG72 scFv to FasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAG72 as well as the biological activity of FasL. This antibody-cytokine fusion protein is highly effective in in vitro killing of human TAG-72+ Jurkat-Ras tumor cells with a 30,000 fold greater cytotoxicity as compared to soluble FasL (sFasL). ScFv-FasLext with a strong cytotoxicity against sensitive human tumor targets may be useful as effective chemotherapeutic agents. This immunocytokine was designed for treating human Jurkat-Ras cancer.      

Specifications
Target
TAG72
Molecule Class
scFv-FasL
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
cc49
Related Disease
human Jurkat-Ras cancer
Cytokines 1
FasL
Cytokines 1 Description
Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
CA 72.4; TAG 72; Tumor associated Glycoprotein 72; TAG72

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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