Anti-TAG72 Antibody-Cytokine Fusion Protein, scFv (cc49)-FasL (CAT#: ACFP-SH018)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAG72 scFv to FasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAG72 as well as the biological activity of FasL. This antibody-cytokine fusion protein is highly effective in in vitro killing of human TAG-72+ Jurkat-Ras tumor cells with a 30,000 fold greater cytotoxicity as compared to soluble FasL (sFasL). ScFv-FasLext with a strong cytotoxicity against sensitive human tumor targets may be useful as effective chemotherapeutic agents. This immunocytokine was designed for treating human Jurkat-Ras cancer.
Specific Inquiry
Specifications
- Target
- TAG72
- Molecule Class
- scFv-FasL
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- cc49
- Related Disease
- human Jurkat-Ras cancer
- Cytokine 1
- FasL
- Cytokines 1 Description
- Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- CA 72.4; TAG 72; Tumor associated Glycoprotein 72; TAG72
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone CC49"
See other products for "TAG72"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-723 | Mouse Anti-TAG72 Recombinant Antibody (clone Anatumomab); Fab Fragment | FuncS, IF, Neut, ELISA, FC, IP, WB | Mouse Fab (IgG1, κ) |
| TAB-H60 | Anti-Human TAG-72 Recombinant Antibody (Satumomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-249 | Anti-Human TAG-72 Recombinant Antibody (Minretumomab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| TAB-002 | Anti-Human TAG72 Recombinant Antibody (Satumomab Pendetide) | IP, IF, FuncS, FC, Neut, ELISA, WB | IgG1 |
| PABX-025-S (P) | Recombinant Human Anti-TAG-72 Antibody scFv Fragment (B72.3) | WB, Neut, FuncS | scFv |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L070E | anti-TAG72 immunotoxin CC49 (scFv)-PE | Cytotoxicity assay, Functional assay |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2) | WB, ELISA | Humanized IgG |
| FAMAB-0278YC | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49) | FuncS | Mouse IgG |
| FAMAB-0279YC | Human Anti-TAG72 Recombinant Antibody (clone cCC49) | FuncS | Chimeric (mouse/human) IgG |
| FAMAB-0280YC | Human Anti-TAG72 Recombinant Antibody (clone HuCC49) | FuncS | Humanized IgG |
| FAMAB-0315CQ | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19) | IHC | Mouse IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2); scFv Fragment | WB, ELISA | Humanized scFv |
| FAMAB-0278-YC-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49); scFv Fragment | FuncS | Mouse scFv |
| FAMAB-0279-YC-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone cCC49); scFv Fragment | FuncS | Mouse scFv |
| FAMAB-0280-YC-S(P) | Human Anti-TAG72 Recombinant Antibody (clone HuCC49); scFv Fragment | FuncS | Humanized scFv |
| FAMAB-0315CQ-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); scFv Fragment | ELISA | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0285CL | Human Anti-TAG72 Recombinant Antibody (TAB-0285CL) | DB, IHC, BI, SPR | Human IgG |
| TAB-0286CL | Human Anti-TAG72 Recombinant Antibody (TAB-0286CL) | DB, IHC, BI, SPR | Human IgG |
| TAB-0285CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0285CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
| TAB-0286CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0286CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
| TAB-0285CL-F(E) | Human Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-0285CL-F(E)) | DB, IHC, BI, SPR | Human Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-505CT | Humanized Anti-TAG72 Recombinant Antibody (TAB-505CT) | WB, ELISA | Humanized antibody |
| TAB-505CT-S(P) | Humanized Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-505CT-S(P)) | WB, ELISA | Humanized scFv |
| TAB-505CT-F(E) | Humanized Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-505CT-F(E)) | WB, ELISA | Humanized Fab |
| PABX-025 | Recombinant Human Anti-TAG-72 Antibody (B72.3) | WB, Neut, FuncS, ELISA, Cyt | IgG |
| PABX-025-F (E) | Recombinant Human Anti-TAG-72 Antibody Fab Fragment (B72.3 ) | WB, Neut, FuncS | Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-016LC | Recombinant Anti-Human TAG-72 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0278-YC-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49); Fab Fragment | FuncS | Mouse Fab |
| FAMAB-0279-YC-F(E) | Human Anti-TAG72 Recombinant Antibody (clone cCC49); Fab Fragment | FuncS | Human Fab |
| FAMAB-0280-YC-F(E) | Human Anti-TAG72 Recombinant Antibody (clone HuCC49); Fab Fragment | FuncS | Humanized Fab |
| FAMAB-0315CQ-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0316CQ-F(E) | Human Anti-TAG72 Recombinant Antibody (clone cACT19); Fab Fragment | ELISA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-249 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody (Minretumomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-H60 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody (Satumomab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for ACFP-SH018. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.