Products

Anti-TAL6 Immunocytokine, scFv (L6)-IL2 (ACFP-SH050)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAL6 scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAL6 as well as the biological activity of IL2. Because interleukin-2 induces lymphocyte proliferation, fused antibody that targets interleukin-2 (IL-2) to a malignant or infected tissue can produce localized amplification of the immune response toward the diseased tissue, and thereby facilitate the destruction of the infected or malignant tissue. This immunocytokine was designed for treating carcinomas of the breast, colon, lung, and ovary.      

Specifications
Target
TAL6
Molecule Class
scFv-IL2
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
L6
Related Disease
Carcinomas of the breast, colon, lung, and ovary
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
TM4SF1; transmembrane 4 L six family member 1; L6; H-L6; M3S1; TAAL6; transmembrane 4 L6 family member 1; tumor-associated antigen L6
Entrez Gene ID
4071
UniProt ID
P30408

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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