Products

Anti-TAL6 Immunocytokine, scFv (L6)-PF4 (ACFP-SH051)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAL6 scFv to PF4. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAL6 as well as the biological activity of PF4. The antibody-based fusion protein may be used to inhibit angiogenesis at a tumor site and thereby inhibit tumor growth. This immunocytokine was designed for treating carcinomas of the breast, colon, lung, and ovary.      

Specifications
Target
TAL6
Molecule Class
scFv-PF4
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
L6
Related Disease
Carcinomas of the breast, colon, lung, and ovary
Cytokines 1
PF4
Cytokines 1 Description
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4). This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
TM4SF1; transmembrane 4 L six family member 1; L6; H-L6; M3S1; TAAL6; transmembrane 4 L6 family member 1; tumor-associated antigen L6
Entrez Gene ID
4071
UniProt ID
P30408

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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