Recombinant Anti-human TERT Intrabody [Tat] (CAT#: IAB-B046(T))

Recombinant anti-TERT intrabody in fusion with HIV Tat works within cells to bind human TERT, expressed in CHO cells. The intrabody can directed against hTERT to attenuate the immortalization of human uterine cervix and hepatoma cells.


Specific Inquiry
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  • Purity:
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • human telomerase reverse transcriptase
  • Host Species
  • human
  • Type
  • scFv-Tat
  • Cell Penetrating Peptide
  • TAT
    TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
  • Species Reactivity
  • human
  • Applications
  • Can be useful in applications such as: Western blot; Immunocytochemistry; Neutralization; Functional studies

Product Property

  • Purity
  • >95% by HPLC
  • Storage
  • 4°C or -20°C, avoid repeated freezing and thawing.

Target

  • Alternative Names
  • TERT; telomerase reverse transcriptase; TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1; telomerase catalytic subunit; telomerase-associated protein 2

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "TERT"

Fab Fragment Antibody

scFv Fragment Antibody

Single-domain Antibody

CAT Product Name Application Type
NABL-050 Recombinant Anti-human TERT VHH Single Domain Antibody WB, ELISA, IP, FuncS Llama VHH

Intrabody

CAT Product Name Application Type
IAB-B046(A) Recombinant Anti-human TERT Intrabody [(D-Arg)9] PCA, Neut, FuncS scFv-(D-Arg)9
IAB-B046(G) Recombinant Anti-human TERT Intrabody [+36 GFP] WB, Neut, FuncS scFv-(+36GFP)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0581MZ Chicken Anti-TERT Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3533 Rabbit Anti-TERT Recombinant Antibody (clone DS3533AB) FC, ICC, IF, IHC-Fr, IHC-P, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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