This immunotoxin was achieved by conjugating/fusing the Anti-TFRC monoclonal antibody to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of leptomeningeal carcinomatosis.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1176z-S(P) | Recombinant Anti-Human TFRC Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
FAMAB-0281-YC-S(P) | Mouse Anti-TFRC Recombinant Antibody (clone OX26); scFv Fragment | ELISA | Mouse scFv |
HPAB-597-FY-S(P) | Human Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-597-FY-S(P)) | ELISA | Humanized scFv |
HPAB-2579LY-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-2579LY-S(P)) | ELISA | Mouse scfv |
HPAB-2624LY-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-2624LY-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G067E | Anti-TFRC immunotoxin HB21 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G067D | Anti-TFRC immunotoxin HB21 (scFv)-DT | Cytotoxicity assay, Function study | |
AGTO-G067G | Anti-TFRC immunotoxin HB21 (scFv)-Gel | Cytotoxicity assay, Function study | |
AGTO-G067R | Anti-TFRC immunotoxin HB21 (scFv)-RTA | Cytotoxicity assay, Function study | |
AGTO-G067S | Anti-TFRC immunotoxin HB21 (scFv)-Sap | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0464CL-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-0464CL-F(E)) | FuncS | Mouse Fab |
TAB-0465CL-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-0465CL-F(E)) | FuncS | Mouse Fab |
TAB-0466CL-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-0466CL-F(E)) | FuncS | Mouse Fab |
TAB-615CT | Anti-Human TfR Recombinant Antibody (6-90) | ELISA, WB, IP | |
TAB-616CT | Anti-Human TfR Recombinant Antibody (55-31) | ELISA, WB, IP |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-611CT | Humanized Anti-TFRC Recombinant Antibody (TAB-611CT) | ELISA | Humanized IgG |
TAB-611CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-611CT-S(P)) | ELISA | Humanized scFv |
TAB-612CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-612CT-S(P)) | ELISA | Humanized scFv |
TAB-613CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-613CT-S(P)) | ELISA | Humanized scFv |
TAB-614CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-614CT-S(P)) | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-619CT-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-619CT-F(E)) | ELISA, WB | Human Fab |
TAB-620CT-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-620CT-F(E)) | ELISA, WB | Human Fab |
TAB-621CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (LUCA31) | ELISA, WB, FC | Human antibody |
TAB-623CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (3TF12) | WB | Human antibody |
TAB-624CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (3TF2) | WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1999CQ | Rat Anti-Tfrc Recombinant Antibody (clone RI7217) | FC, ICC, IP, WB, Block | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3548 | Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) | FC, IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC3370 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTGKL) MHC Tetramer | FCM | |
MHC-LC3371 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTG) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0376-CN | Mouse Anti-TFRC Recombinant Antibody (HPAB-0376-CN) | ELISA, FC | Mouse IgG |
HPAB-0377-CN | Mouse Anti-TFRC Recombinant Antibody (HPAB-0377-CN) | ELISA, FC | Mouse IgG |
HPAB-0378-CN | Mouse Anti-TFRC Recombinant Antibody (HPAB-0378-CN) | ELISA, FC | Mouse IgG |
HPAB-0379-CN | Human Anti-TFRC Recombinant Antibody (HPAB-0379-CN) | ELISA, FC | Humanized IgG |
HPAB-0380-CN | Mouse Anti-TFRC Recombinant Antibody (clone BA120G) | ELISA, FC, IF, IP | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0376-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0376-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0377-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0377-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0378-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0378-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0379-CN-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0379-CN-F(E)) | ELISA, FC | Humanized Fab |
HPAB-0380-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody (clone BA120G); Fab Fragment | ELISA, FC, IF, IP | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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