Anti-TFRC immunotoxin 454A12 (IgG)-RTA (CAT#: AGTO-G068R)

This immunotoxin was achieved by conjugating/fusing the Anti-TFRC monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of leptomeningeal carcinomatosis.


Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • 454A12
  • Molecule Class
  • IgG-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Leptomeningeal carcinomatosis

Target

  • Alternative Names
  • TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90, CD71); Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G067E Anti-TFRC immunotoxin HB21 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G067D Anti-TFRC immunotoxin HB21 (scFv)-DT Cytotoxicity assay, Function study
AGTO-G067G Anti-TFRC immunotoxin HB21 (scFv)-Gel Cytotoxicity assay, Function study
AGTO-G067R Anti-TFRC immunotoxin HB21 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G067S Anti-TFRC immunotoxin HB21 (scFv)-Sap Cytotoxicity assay, Function study

Blocking Antibody

CAT Product Name Application Type
NEUT-1999CQ Rat Anti-Tfrc Recombinant Antibody (clone RI7217) FC, ICC, IP, WB, Block Rat IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3548 Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) FC, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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