Products

Anti-TFRC immunotoxin 454A12 (IgG)-RTA (AGTO-G068R)

This immunotoxin was achieved by conjugating/fusing the Anti-TFRC monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of leptomeningeal carcinomatosis.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
454A12
Molecule Class
IgG-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Leptomeningeal carcinomatosis
Target
Alternative Names
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1
Entrez Gene ID
7037
UniProt ID
P02786

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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