Anti-TGFB1 Recombinant Antibody (Metelimumab) (CAT#: TAB-762)
Recombinant human monoclonal antibody expressed in CHO binding to human TGFB1. Metelimumab is a human IgG4 monoclonal antibody that neutralizes TGF beta 1 which had been chosen for further development for the treatment of diffuse cutaneous systemic sclerosis, also known as scleroderma.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Figure 3 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Figure 4 Bone marrow
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG4 - kappa
- Species Reactivity
- Human
- Applications
- Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
- CAS
- 272780-74-2
- Generic Name
- metelimumab
- Related Disease
- Scarring
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- metelimumab;272780-74-2;CAT-192;TGFB1;transforming growth factor, beta 1;DPD1, TGFB;transforming growth factor beta-1;Camurati Engelmann disease;CED;TGFbeta;TGF-beta-1;TGF-beta 1 protein;latency-associated peptide;LAP;DPD1;TGFB;
- Gene ID
- 7040
- UniProt ID
- P01137
Related Resources
Please refer to Metelimumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Metelimumab.
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Metelimumab"
Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Metelimumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human monoclonal antibody expressed in CHO binding to human TGFB1. Metelimumab is a human IgG4 monoclonal antibody that neutralizes TGF beta 1 which had been chosen for further development for the treatment of diffuse cutaneous systemic sclerosis, also known as scleroderma.
See other products for "Tgfb1"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-632CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-632CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-633CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-633CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-634CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-634CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-632CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-632CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-633CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-633CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-635CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-636CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-636CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-637CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-637CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-638CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-638CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-639CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-639CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0853MZ | Chicken Anti-TGF beta-1 Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
| BRD-1095MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to APC | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1096MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to AP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1097MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to AMCA | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1098MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
| NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (clone TW7-28G11) | FC, WB, IP, Neut | Mouse IgG2b, κ |
| NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (clone TW7-20B9) | FC, IP, Neut, WB | Mouse IgG1, κ |
| NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 2Ar2) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-YC | Human Anti-TGFB1 Recombinant Antibody (HPAB-0018-YC) | ELISA, Neut | Humanized IgG, κ |
| HPAB-N0392-YC | Human Anti-TGFB1 Recombinant Antibody (HPAB-N0392-YC) | ELISA, Inhib | Human IgG |
| HPAB-N0393-YC | Human Anti-TGFB1 Recombinant Antibody (HPAB-N0393-YC) | ELISA, Inhib | Human IgG |
| HPAB-N0394-YC | Human Anti-TGFB1 Recombinant Antibody (HPAB-N0394-YC) | IHC, Neut, FuncS | Human IgG4 |
| HPAB-2101-FY | Human Anti-TGFB1 Recombinant Antibody (clone SL15A) | Inhib, ELISA | Human IgG4, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0018-YC-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0308CQ-S(P) | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 2471); scFv Fragment | ELISA, Neut, FC | Mouse scFv |
| HPAB-0309CQ-S(P) | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 1021); scFv Fragment | ELISA, Neut, FC | Mouse scFv |
| HPAB-0310CQ-S(P) | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 3821); scFv Fragment | ELISA, Neut, FC | Mouse scFv |
| HPAB-2107-FY-S(P) | Human Anti-TGFB1 Recombinant Antibody (clone 31G9); scFv Fragment | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0492-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0492-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
| HPAB-0493-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0493-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
| HPAB-0494-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0494-CN-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0495-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0495-CN-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0496-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0496-CN-F(E)) | ELISA, Neut | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-140 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Fresolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody (Metelimumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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