Anti-THY1 immunotoxin OX7 (F (ab')2)-RTA (CAT#: AGTO-G060R)

This immunotoxin was achieved by conjugating/fusing the Anti-THY1 F(ab')2 to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to THY 1-expressing cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of lymphoma.


Specific Inquiry
  • Size:
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  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • OX7
  • Molecule Class
  • F(ab')2-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • lymphoma

Target

  • Alternative Names
  • THY1; Thy-1 cell surface antigen; CD90; thy-1 membrane glycoprotein; CDw90; thy-1 antigen; Thy-1 T-cell antigen; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone OX7"

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Fab Fragment Antibody

CAT Product Name Application Type
MOB-1495z-F(E) Recombinant Anti-Human THY1 Antibody Fab Fragment FC, WB, FuncS Fab

Immunotoxin

CAT Product Name Application Type
AGTO-G060S Anti-THY1 immunotoxin OX7 (F (ab')2)-Sap Cytotoxicity assay, Function study
AGTO-L040R anti-THY1 immunotoxin AT15E (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L040S anti-THY1 immunotoxin AT15E (IgG)-Sap Cytotoxicity assay, Functional assay
AGTO-L060S anti-Thy1 immunotoxin OX7 (IgG)-Sap Cytotoxicity assay, Functional assay

Blocking Antibody

CAT Product Name Application Type
NEUT-2023CQ Rat Anti-THY1 Recombinant Antibody (clone YKIX337.217) Block, FC Rat IgG2b

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3568 Rabbit Anti-THY1 Recombinant Antibody (clone DS3568AB) ICC, IHC-P, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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