Products

Anti-THY1 immunotoxin OX7 (F (ab')2)-RTA (AGTO-G060R)

This immunotoxin was achieved by conjugating/fusing the Anti-THY1 F(ab')2 to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to THY 1-expressing cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of lymphoma.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
OX7
Molecule Class
F(ab')2-RTA
Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
lymphoma
Target
Alternative Names
THY1; Thy-1 cell surface antigen; CD90; thy-1 membrane glycoprotein; CDw90; thy-1 antigen; Thy-1 T-cell antigen; Deglycosylated ricin A chain
Entrez Gene ID
7070
UniProt ID
B0YJA4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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