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Anti-TLR2 Intrabody [+36GFP] (IAB-B030(G))

Recombinant anti-TLR2 intrabody in fusion with +36GFP works within cells towards TLR2, expressed in CHO cells. Intracellular antibodiess expressed and retained inside the endoplasmatic reticulum (ER-intrabodies) are applied to block translocation of secreted and cell surface molecules from the ER to the cell surface resulting in functional inhibition of the target protein. since cell activation via TLR2 and other pattern recognition receptors (PRRs) contributes to sepsis pathology and chronic inflammation both relying on overamplification of an immune response.      

Specifications
Immunogen
Toll-like receptor (TLR) 2
Host
murine
Type
scFv-(+36GFP)
Cell Penetrating Peptide
+36 GFP
GFP with a theoretical net charge of +36 (+36 GFP) penetrated several different mammalian cell lines at very low (nanomolar) concentrations. Cationic peptides and proteins have been observed to penetrate cells, and both natural and synthetic cell-penetrating peptides are widely used as delivery vehicles. However, whereas a covalent link between the cell-penetrating peptide and its cargo is typically required.
Applications
Antibody assay: Enzyme-linked Immunosorbent Assay; Western blot; Immunocytochemistry; Functional studies
Target
Alternative Names
CD282; CD282 antigen; TIL 4; TLR 2; TLR2; TLR2_HUMAN; Toll like receptor 2; Toll like receptor 2 precursor

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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