Anti-TNFRSF12A immunotoxin ITEM-4 (scFv)-Gel (AGTO-G061G)
This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF12A scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF12A overexpressed tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating malignant melanoma.
- Species Reactivity
- Molecule Class
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Malignant Melanoma
- Alternative Names
- TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; FN14; CD266; TWEAKR; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14
- Entrez Gene ID
- UniProt ID
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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