Anti-TNFRSF12A immunotoxin ITEM-4 (scFv)-Gel (CAT#: AGTO-G061G)

This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF12A scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF12A overexpressed tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating malignant melanoma.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • ITEM-4
  • Molecule Class
  • scFv-Gel
  • Toxin Description
  • Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Malignant Melanoma

Target

  • Alternative Names
  • TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; FN14; CD266; TWEAKR; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14; Gelonin; Gel

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone ITEM-4"

See other products for "TNFRSF12A"

Chimeric Antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-194LC Recombinant Anti-Human TNFRSF12A Antibody (Non-glycosylated) ELISA Humanized antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3610 Rabbit Anti-TNFRSF12A Recombinant Antibody (clone DS3610AB) IHC-P, WB Rabbit IgG

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for AGTO-G061G. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare