Products

Anti-TNFRSF12A immunotoxin ITEM-4 (scFv)-Gel (AGTO-G061G)

This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF12A scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to TNFRSF12A overexpressed tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating malignant melanoma.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
ITEM-4
Molecule Class
scFv-Gel
Toxin Description
Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Malignant Melanoma
Target
Alternative Names
TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; FN14; CD266; TWEAKR; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14
Entrez Gene ID
51330
UniProt ID
Q9NP84

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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