anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-PE (CAT#: AGTO-L041E)

This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF8 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to lymphoma cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of lymphoma.


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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Cell Penetrating Peptide
  • A5D8T4
  • Species Reactivity
  • Human
  • Clone
  • Ber-H2
  • Molecule Class
  • L kappa; IgG1-PE
  • Toxin Description
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Lymphoma

Target

  • Alternative Names
  • TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30; Lymphoma; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone Ber-H2"

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Human Antibody

CAT Product Name Application Type
TAB-144 Anti-Human CD30 Recombinant Antibody (Iratumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Chimeric Antibody

CAT Product Name Application Type
TAB-153 Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (clone Brentuximab) Neut, ELISA, IF, IP, FuncS, FC, ICC Human IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G062E Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G062R Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G062S Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap Cytotoxicity assay, Function study
AGTO-L041R anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L041S anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-Sap Cytotoxicity assay, Functional assay

Humanized Antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-139LC Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-139LC-1 Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0597MZ Chicken Anti-TNFRSF8 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2165CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1) FC, Stim, Costim, Block Hamster IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2166CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F) Neut, FC Hamster IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-144 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Iratumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-153 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Brentuximab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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