Rabbit Anti-MAPT Recombinant Antibody (clone RB86) (CAT#: PABL-713)

Recombinant Rabbit Antibody (RB86) is capable of binding to Tau.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Monoclonal antibody DC8E8 inhibits pathological tau–tau interaction.

Figure 1 Monoclonal antibody DC8E8 inhibits pathological tau–tau interaction.

(A) Tau western blots using MAb86 (top) and human tau-specific antibody HT7 (bottom) for detection. MAb86 binds specifically to ERK-phosphorylated tau (lane 1) but not to unphosphorylated tau (lane 2), ERK-phosphorylated mutant tau S422A (lane 3) or unphosphorylated tau S422A (lane 4). (B) Western blots of brain extracts from TauPS2APP mouse brains using MAb86 (top) and human tau-specific antibody HT7 (bottom) for detection. Extracts were prepared from 16-month-old wild-type mice (lane 1) or triple transgenic mice at 8, 12, 16 and 20 months of age (lanes 2-5). M = molecular weight markers.

Collin, L., Bohrmann, B., Göpfert, U., Oroszlan-Szovik, K., Ozmen, L., & Grüninger, F. (2014). Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease. Brain, 137(10), 2834-2846.

Figure 2 Tau/pS422 locates in lipid raft microdomains on neuronal membranes in untreated TauPS2APP mice.

Figure 2 Tau/pS422 locates in lipid raft microdomains on neuronal membranes in untreated TauPS2APP mice.

(A-D) Pathological tau/ pS422 is detected in lipid raft-like microdomains on the periphery of a dendritic shaft (A and B). (C and D) High magnification of the boxed area in B. Microtubule cytoskeleton is in green (B and D), nuclei are counterstained with DAPI in B. (E-G) Tau/pS422 partially localizes with flotillin 1 as indicated by arrows.

Collin, L., Bohrmann, B., Göpfert, U., Oroszlan-Szovik, K., Ozmen, L., & Grüninger, F. (2014). Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease. Brain, 137(10), 2834-2846.


Specifications

  • Immunogen
  • Human microtubule-associated protein tau
  • Host Species
  • Rabbit
  • Derivation
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human MAPT
  • Species Reactivity
  • Human
  • Clone
  • RB86
  • Applications
  • WB, IF, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; protein phosphatase 1, regulatory subunit 103; G protein beta1/gamma2 subunit-interacting factor 1

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone RB86"

See other products for "MAPT"

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0733MZ Chicken Anti-TAU Polyclonal IgY ICC/IF, IHC, WB Chicken antibody

Mouse Antibody

CAT Product Name Application Type
PABX-174 Recombinant Mouse Anti-Tau5 Antibody WB, ELISA, Neut, FuncS IgG
PABX-174-S (P) Recombinant Mouse Anti-Tau5 Antibody scFv Fragment WB, ELISA, Neut, FuncS scFv
PABX-174-F (E) Recombinant Mouse Anti-Tau5 Antibody Fab Fragment WB, ELISA, Neut, FuncS Fab

Neuroscience Antibody

CAT Product Name Application Type
NS-090CN Mouse Anti-MAPT Recombinant Antibody (NS-090CN) WB, ELISA, IHC, IP, SPR, FuncS Mouse IgG2b

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for PABL-713. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare