Anti-Human Tau Recombinant Antibody (pT231/pS235_1) (CAT#: TAB-530CT)
Recombinant monoclonal antibody specifically binds to phospho-tau with high affinity. This antibody can be potentially used in treating Alzheimer's Disease.
Specific Inquiry
WB
Figure 1 Expression and binding activity of chimeric IgG molecules converted from scFv.
Western blot analysis of chimeric IgG molecules convertedfrom scFv clones pT231/pS235_1, pS396/pS404_1, and pT212/pS214_1, respectively. The heavy and light chains for each IgG are indicated by arrows.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
ELISA
Figure 2 Expression and binding activity of chimeric IgG molecules converted from scFv.
ELISA analysis of each purified IgG molecule for binding to the phosphopeptide, non-phosphopeptide, and scrambled (Scr) peptide.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
IHC
Figure 3 Binding of pathological phospho-tau by antibody pT231/pS235_1 in human AD and Tg4510 transgenic mouse brains.
Immunohisto-chemical staining of human AD brain (Aand B) and healthy brain.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
WB
Figure 4 Western blot analysis of Tg4510 transgenic andwild-type brain lysates with pT231/pS235_1 IgG (plus control anti-GAPDH antibody).
Each lane represents a different animal, and the lysate samples are3-month-old wild-type mice (lanes 1 and 2), 3-month-old transgenic mice (lanes 3 and 4), 6-month-old wild-type mice (lanes 5 and 6), and 6-month-oldtransgenic mice (lanes 7 and 8).
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
Specifications
- Host Species
- Chicken
- Derivation
- Phage display library
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- pT231/pS235_1
- Applications
- WB, ELISA, IHC
- Related Disease
- Alzheimer's Disease
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Immunohistochemistry and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-951 | Recombinant Anti-Tau Antibody | ELISA, WB, IP, FuncS | IgG |
| MOB-091LC | Recombinant Humanized Anti-TAU Recombinant Antibody (huHJ8) | ELISA, FuncS | Humanized IgG |
| HPAB-0773LY | Human Anti-Tau Recombinant Antibody (HPAB-0773LY) | ELISA | Human IgG |
| HPAB-2561LY | Human Anti-Tau Recombinant Antibody (HPAB-2561LY) | WB, IHC, ELISA | Humanized IgG1 |
| HPAB-S0178-YC | Mouse Anti-Tau Recombinant Antibody (clone Tau5) | ELISA | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-951-F(E) | Recombinant Anti-Tau Antibody Fab Fragment | IP, FuncS | Fab |
| MHH-951-F(E) | Recombinant Human Anti-Tau Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| HPAB-0773LY-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (HPAB-0773LY-F(E)) | ELISA | Human Fab |
| HPAB-S0178-YC-F(E) | Mouse Anti-Tau Recombinant Antibody (clone Tau5); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0352WJ-F(E) | Mouse Anti-Tau Recombinant Antibody (clone MHT2); Fab Fragment | ELISA, WB, IHC | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0427CL | Human Anti-Tau Recombinant Antibody (TAB-0427CL) | ELISA, WB, IHC, FuncS | Human IgG |
| TAB-0428CL | Human Anti-Tau Recombinant Antibody (TAB-0428CL) | ELISA, WB | Human IgG |
| TAB-0429CL | Human Anti-Tau Recombinant Antibody (TAB-0429CL) | ELISA, WB | Human IgG |
| TAB-0427CL-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (TAB-0427CL-F(E)) | ELISA, WB, IHC, FuncS | Human Fab |
| TAB-0428CL-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (TAB-0428CL-F(E)) | ELISA, WB | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-519CT | Mouse Anti-Tau Recombinant Antibody (TAB-519CT) | WB, ELISA | Mouse IgG |
| TAB-520CT | Mouse Anti-Tau Recombinant Antibody (TAB-520CT) | WB, ELISA | Mouse IgG |
| TAB-521CT | Mouse Anti-Tau Recombinant Antibody (TAB-521CT) | WB, ELISA | Mouse IgG |
| TAB-522CT | Mouse Anti-Tau Recombinant Antibody (TAB-522CT) | ELISA, IF, WB | Mouse IgG |
| TAB-523CT | Mouse Anti-Tau Recombinant Antibody (TAB-523CT) | WB, ELISA | Mouse IgG2a |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-527CT | Human Anti-Tau Recombinant Antibody (TAB-527CT) | IF, FuncS | Humanized antibody |
| TAB-533CT | Humanized Anti-Tau Recombinant Antibody (TAB-533CT) | WB, Inhib, IHC, FuncS, IF | Humanized IgG |
| TAB-527CT-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (TAB-527CT-S(P)) | WB, ELISA, IHC | Human scFv |
| TAB-533CT-S(P) | Humanized Anti-Tau Recombinant Antibody; scFv Fragment (TAB-533CT-S(P)) | WB, ELISA, IP, IHC, Neut | Humanized scFv |
| TAB-527CT-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (TAB-527CT-F(E)) | WB, ELISA, IHC | Humanized Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2561LY-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (HPAB-2561LY-S(P)) | WB, IHC, ELISA | Human scFv |
| HPAB-2562LY-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (HPAB-2562LY-S(P)) | WB, IHC, ELISA | Human scFv |
| HPAB-2563LY-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (HPAB-2563LY-S(P)) | WB, IHC, ELISA | Humanized scfv |
| MOB-0054SW-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (MOB-0054SW-S(P)) | ELISA, FuncS | Humanized scFv |
| FAMAB-0352WJ-S(P) | Mouse Anti-Tau Recombinant Antibody (clone MHT2); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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