Anti-TfR Antibody-Cytokine Fusion Protein, IgG (ch17217)-GM-CSF (CAT#: ACFP-SH022)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TfR IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TfR as well as the biological activity of GM-CSF. This antibody-cytokine fusion protein can potentially be used against different tumor types due to TfR overexpression in a wide variety of cancer malignances. This immunocytokine was designed for treating TfR overexpression cancer malignances.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • TfR
  • Molecule Class
  • IgG2b-GM-CSF
  • Species Reactivity
  • Mouse
  • Expression Host
  • CHO
  • Clone
  • ch17217
  • Related Disease
  • TfR overexpression cancer malignances
  • Cytokine 1
  • GM-CSF
  • Cytokines 1 Description
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
  • Cytokine 1 Species
  • Mouse
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G067E Anti-TFRC immunotoxin HB21 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G067D Anti-TFRC immunotoxin HB21 (scFv)-DT Cytotoxicity assay, Function study
AGTO-G067G Anti-TFRC immunotoxin HB21 (scFv)-Gel Cytotoxicity assay, Function study
AGTO-G067R Anti-TFRC immunotoxin HB21 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G067S Anti-TFRC immunotoxin HB21 (scFv)-Sap Cytotoxicity assay, Function study

Blocking Antibody

CAT Product Name Application Type
NEUT-1999CQ Rat Anti-Tfrc Recombinant Antibody (clone RI7217) FC, ICC, IP, WB, Block Rat IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3548 Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) FC, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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