Anti-Tissue factor (TF-011)-vc-MMAE ADC (HuMax-TF ADC) (CAT#: ADC-L015)
This ADC product is composed of an anti-Tissue factor antibody (clone TF-011) conjuagated via a vc linker to MMAE (TF-011-vc-MMAE). It has demonstrated a response in Prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Liver
(Hepatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_4.jpg
(Hepatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_4.jpg
Figure 2 Kidney
(Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_5.jpg
(Cells in tubules
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5692/159943_A_8_5.jpg
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000091513-TF
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000091513-TF
Figure 3 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091513-TF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000091513-TF
Specifications
- Antibody Overview
- Fully human IgG1K monoclonal antibody that binds to TF
- Clone
- TF-011
- Antibody Conjugation
- Human
- Linker
- vc (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading to fibrin formation.
- Alternative Names
- TF; Tissue factor
Related Resources
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Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TF"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-343 | Mouse Anti-TF Recombinant Antibody (clone 6A6); scFv Fragment | WB, ELISA, IF, FuncS | Mouse scFv |
| HPAB-2578LY-S(P) | Human Anti-TF Recombinant Antibody; scFv Fragment (HPAB-2578LY-S(P)) | ELISA | Humanized scfv |
| HPAB-M0321-YC-S(P) | Human Anti-TF Recombinant Antibody; scFv Fragment (HPAB-M0321-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-0494-YJ-S(P) | Mouse Anti-TF Recombinant Antibody (clone CBT61YJ); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-1276WJ-S(P) | Mouse Anti-TF Recombinant Antibody; scFv Fragment (HPAB-1276WJ-S(P)) | ELISA | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-121 | Mouse Anti-TF Recombinant Antibody (clone 5G9); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
| PFBW-164 | Mouse Anti-TF Recombinant Antibody (clone JAA-F11); Fab Fragment | FuncS | Mouse Fab |
| HPAB-0767-CN-F(E) | Human Anti-TF Recombinant Antibody; Fab Fragment (HPAB-0767-CN-F(E)) | WB, ELISA, FC, IHC | Human Fab |
| HPAB-0768-CN-F(E) | Human Anti-TF Recombinant Antibody; Fab Fragment (HPAB-0768-CN-F(E)) | WB, ELISA, FC, IHC | Human Fab |
| HPAB-0769-CN-F(E) | Human Anti-TF Recombinant Antibody; Fab Fragment (HPAB-0769-CN-F(E)) | WB, ELISA, FC, IHC | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0510CL | Mouse Anti-TF Recombinant Antibody (TAB-0510CL) | WB, IF, ELISA | Mouse IgG |
| TAB-0510CL-S(P) | Mouse Anti-TF Recombinant Antibody; scFv Fragment (TAB-0510CL-S(P)) | WB, IF, ELISA | Mouse scFv |
| TAB-0510CL-F(E) | Mouse Anti-TF Recombinant Antibody; Fab Fragment (TAB-0510CL-F(E)) | WB, IF, ELISA | Mouse Fab |
| TAB-598CT | Mouse Anti-TF Recombinant Antibody (TAB-598CT) | ELISA, FC | Mouse IgG1. κ |
| TAB-598CT-S(P) | Mouse Anti-TF Recombinant Antibody; scFv Fragment (TAB-598CT-S(P)) | ELISA, FC | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-599CT | Anti-Human TF Recombinant Antibody (ATR-5) | ELISA, FC | Humanized antibody |
| TAB-600CT | Anti-Human TF Recombinant Antibody (ATR-2) | ELISA, FC | Humanized antibody |
| TAB-599CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (ATR-5) | ELISA, FC | Humanized antibody |
| TAB-600CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (ATR-2) | ELISA, FC | Humanized antibody |
| TAB-601CT-S(P) | Anti-Human TF Recombinant Antibody scFv Fragment (ATR-8) | ELISA, FC, BL | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-602CT-F(E) | Anti-Human TF Recombinant Antibody Fab Fragment (3e10) | ELISA, BL | Human antibody |
| TAB-603CT-F(E) | Anti-Human TF Recombinant Antibody Fab Fragment (3h2) | ELISA, BL | Human antibody |
| TAB-604CT-F(E) | Anti-Human TF Recombinant Antibody Fab Fragment (2c1) | ELISA, BL | Human antibody |
| TAB-605CT-F(E) | Anti-Human TF Recombinant Antibody Fab Fragment (2c11) | ELISA, BL | Human antibody |
| TAB-606CT-F(E) | Anti-Human TF Recombinant Antibody Fab Fragment (2d3) | ELISA, BL | Human antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-175LC | Recombinant Anti-Human TF Antibody (Non-glycosylated) | ELISA | Mouse antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0860MZ | Chicken Anti-Transferrin Polyclonal IgY | ELISA | Chicken antibody |
MHC Tetramer for Other Applications
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1996CQ | Mouse Anti-TF Recombinant Antibody (clone HTF-14) | WB, Neut, ELISA, ICC, IF, IHC, IHC-P, RIA | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2022CQ | Mouse Anti-TF Recombinant Antibody (clone A68-B/A11) | ELISA, Inhib, IHC-P, IHC-Fr | Mouse IgM |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3535 | Rabbit Anti-TF Recombinant Antibody (clone DS3535AB) | IHC-P, IP, WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0131C | Mouse Anti-TF Recombinant Antibody (clone 10C7) | IHC-P, IF, ELISA | Mouse IgG |
| ZG-0132C | Mouse Anti-TF Recombinant Antibody (clone 10G3) | WB, IHC-P, IF, ELISA | Mouse IgG |
| ZG-0133C | Mouse Anti-TF Recombinant Antibody (clone 1B12) | IHC-P, IF, ELISA | Mouse IgG |
| ZG-0134C | Mouse Anti-TF Recombinant Antibody (clone 2D7) | IHC-P, IF, ELISA | Mouse IgG |
| ZG-0135C | Mouse Anti-TF Recombinant Antibody (clone 2F2) | IHC-P, IF, ELISA | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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