Products

Anti-TnC-A1 Immunocytokine, scFv (F16)-IL2 (ACFP-SH029)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TnC-A1 scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TnC-A1 as well as the biological activity of IL2. F16-IL2, a clinical-stage immunocytokine consisting of human interleukin (IL)-2 fused to the human antibody F16. No human anti-fusion protein antibodies (HAFA) response was detected. This immunocytokine was designed for treating metastatic breast cancer.      

Specifications
Target
TnC-A1
Molecule Class
scFv-IL2
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
F16
Related Disease
Metastatic breast cancer
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
TN; Hxb; Ten; TN-C; AI528729; cytotactin; tenascin-C; C130033P17Rik
Entrez Gene ID
21923
UniProt ID
Q148T5

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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