Anti-V. vulnificus RtxA-1 protein Recombinant Antibody (24RA) (MRO-142MZ) (CAT#: MRO-142MZ)

This anti-Vibrio vulnificus RtxA-1 monoclonal antibody 24RA can be favorably used to prevent and treat diseases caused by Vibrio vulnificus and related infection.


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FuncS

Figure 1 Prophylactic efficacies of anti-RtxA1-C MAbs.

Figure 1 Prophylactic efficacies of anti-RtxA1-C MAbs.

Survival of mice treated with anti-RtxA1-C MAbs. A single dose of purified MAbs (1 mg) or ascitic fluid (200 μl) was passively transferred to 8-week-old CD1 mice via the intraperitoneal (i.p.) route, 4.5 h prior to i.p. infection with 1 × 10⁶ or 8 × 10⁶.

Monoclonal Antibodies against Vibrio vulnificus RtxA1 Elicit Protective Immunity through Distinct Mechanisms

FuncS

Figure 2 Prophylactic efficacies of anti-RtxA2-C MAbs.

Figure 2 Prophylactic efficacies of anti-RtxA2-C MAbs.

Therapeutic effects after intraperitoneal (i.p.) and subcutaneous (s.c.) infections. (A) At 1 h postinfection i.p. with 1 × 10⁶ CFU of V. vulnificus, 8-week-old CD1 mice were passively transferred a single dose of purified MAbs (0.5 or 1 mg), ascitic fluid (200 μl), or saline (PBS) i.p. As shown in Table 2, 21RA, 24RA, and 47RA exhibited significant therapeutic efficacies (P ≤ 0.0008), but 13RA, 45RA, and 50RA did not. Survival curves were constructed using data from more than two independent experiments, each with five to six animals.

Monoclonal Antibodies against Vibrio vulnificus RtxA1 Elicit Protective Immunity through Distinct Mechanisms

WB

Figure 3 Immunoreactivity and cross-protection efficiency of anti-RtxA1-C MAbs against different V. vulnificus strains.

Figure 3 Immunoreactivity and cross-protection efficiency of anti-RtxA1-C MAbs against different V. vulnificus strains.

Monoclonal Antibodies against Vibrio vulnificus RtxA1 Elicit Protective Immunity through Distinct Mechanisms


Specifications

  • Immunogen
  • Recombinant RtxA1 protein
  • Host Species
  • Mouse
  • Specificity
  • Vibrio vulnificus
  • Clone
  • 24RA
  • Applications
  • ELISA, FuncS, WB
  • Related Disease
  • Vibrio vulnificus infections

Applications

  • Application Notes
  • The rtxA1 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Functional Assay, Western Blot.

Target

  • Alternative Names
  • V. vulnificus RtxA-1 protein

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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