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Anti-Vdr Intrabody [(D-Arg)9] (IAB-B056(A))

Recombinant anti-Vdr intrabody linked to (D-Arg)9 works within cells to down regulate the mouse Vdr, expressed in CHO cells.bindThe vitamin D receptor related disorders including skin disorders, immune system disorders, and proliferative disorders.      

Specifications
Immunogen
mouse vitamin D receptor
Host
mouse
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
mouse
Applications
Used for immunoassay techniques such as: Protein fragment complementation; Western blot; Functional studies
Target
Alternative Names
125 dihydroxyvitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 25-dihydroxyvitamin D3 receptor; Member 1; NR1I1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; Protein phosphatase 1, regulatory subunit 163
Entrez Gene ID
22337

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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