Products

Anti-Was Intrabody [Tat] (IAB-B076(T))

Recombinant anti-Was intrabody in fusion with HIV Tat works within cells to bind against the N-terminal domain of Wiskott–Aldrich syndrome protein Was, expressed in CHO cells. The the VH/VL single domain intrabodies are sufficient to knockdown the domain function of target proteins in the cytosol.      

Specifications
Immunogen
mouse Wiskott–Aldrich syndrome protein
Host
mouse
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
mouse
Applications
Can be useful in applications such as: Immunocytochemistry; Neutralization; Functional studies
Target
Alternative Names
Was; Wiskott–Aldrich syndrome protein
Entrez Gene ID
22376

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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