Anti-Human hCG Recombinant Antibody (PIPP) (CAT#: TAB-018CT)

Recombinant monoclonal antibody clone PIPP to hCG. The antibody PIPP was generated in a hybridoma cell line. This antibody intended for the prophylaxis and treatment studies of T- Lymphoblastic leukemia.


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EMSA

Figure 1 Electrophoretic mobility shift assay of affinity purified recombinant proteins.

Figure 1 Electrophoretic mobility shift assay of affinity purified recombinant proteins.

Purified scFv, diabody or chimeric mAb PIPP were incubated with increasing amounts of HCG.

Kathuria, S., Sriraman, R., Nath, R., Sack, M., Pal, R., Artsaenko, O., ... & Finnern, R. (2002). Efficacy of plant-produced recombinant antibodies against HCG. Human Reproduction, 17(8), 2054-2061.

Inhib

Figure 2 Inhibition of HCG induced production of testosterone by Leydig cells through plant-expressed recombinant scFv, diabody and chimeric mAb PIPP.

Figure 2 Inhibition of HCG induced production of testosterone by Leydig cells through plant-expressed recombinant scFv, diabody and chimeric mAb PIPP.

All three plant-expressed recombinant proteins were able to inhibit the stimulation of HCG production in Leydig cells.

Kathuria, S., Sriraman, R., Nath, R., Sack, M., Pal, R., Artsaenko, O., ... & Finnern, R. (2002). Efficacy of plant-produced recombinant antibodies against HCG. Human Reproduction, 17(8), 2054-2061.

Neut

Figure 3 In-vivo neutralization of HCG-induced increase in uterine weight by plant-expressed chimeric mAb PIPP.

Figure 3 In-vivo neutralization of HCG-induced increase in uterine weight by plant-expressed chimeric mAb PIPP.

Plant-produced recombinant antibodies were able to neutralize HCG in vivo.

Kathuria, S., Sriraman, R., Nath, R., Sack, M., Pal, R., Artsaenko, O., ... & Finnern, R. (2002). Efficacy of plant-produced recombinant antibodies against HCG. Human Reproduction, 17(8), 2054-2061.


Specifications

  • Host Species
  • Human
  • Derivation
  • Hybridoma cell line
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • PIPP
  • Applications
  • EMSA, Inhib, Neut, ELISA, FC
  • Related Disease
  • T- Lymphoblastic leukemia

Applications

  • Application Notes
  • The hCG antibody has been reported in applications of Electrophoretic Mobility Shift Assay, Inhibition, Neutralization, Enzyme-linked Immunosorbent Assay, Flow Cytometry.

Target

  • Alternative Names
  • Hcg; Chorionic gonadotropin; CGA; CGB; anti-hCG

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-441 Recombinant Anti-human hCG Antibody ELISA, WB, FC, FuncS IgG
MHH-441 Recombinant Human Anti-human hCG Antibody ELISA, WB, FuncS IgG
PABC-056 Mouse Anti-hCG Recombinant Antibody (clone 3A2) WB, IHC, IF, FuncS Mouse IgG
HPAB-0353-YJ Mouse Anti-HCG Recombinant Antibody (HPAB-0353-YJ) ELISA, Inhib, Immunocontraception Mouse IgG

Humanized Antibody

CAT Product Name Application Type
TAB-018CT-S(P) Anti-Human hCG Recombinant Antibody scFv Fragment (PIPP) EMSA, Inhib, ELISA, FC Humanized antibody
TAB-018CT-F(E) Anti-Human hCG Recombinant Antibody Fab Fragment (PIPP) ELISA, Inhibition, FC Humanized antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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