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Anti-hIL-18Rα (human interleukin-18 receptor alpha) Therapeutic Antibody (2C2) (TAB-208CT)

Recombinant monoclonal antibody to human interleukin-18 receptor alpha. This antibody intended for the prophylaxis and treatment of systemic inflammatory response syndrome (SIRS).      

Specifications
Immunogen
DNA plasmid that contains an hIL-18Rα gene and expresses hIL-18Rα
Host
Mouse
Specificity
Human
Species Reactivity
Human
Clone
2C2
Applications
Used for immunoassay techniques such as: Neutralization; Enzyme-linked Immunosorbent Assay; Blocking
Related Disease
Systemic inflammatory response syndrome (SIRS)
Target
Alternative Names
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
8809
UniProt ID
Q13478

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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