Recombinant Mouse Antibody (TN1) is capable of binding to hTPO163, expressed in Chinese Hamster Ovary cells (CHO). hTPO163 interacts with soluble c-Mpl containing the extracellular cytokine receptor homology domains with 1:2 stoichiometry with the binding constants of 3. 3 × 109 M–1 and 1. 1 × 106 M–1.
Figure 1 Dose-dependent inhibition of rhTPO-induced growth of FDCP-hMpl5 cells by the neutralizing Abs.
rhTPO (14.1 fmol/ml) was preincubated with various concentrations of each Ab. FDCPhMpl5 (1 × 104 cells/well) were then incubated with these mixtures. After three days, the MTS assay was performed. Symbols represent anti-HT1 (●), TN1 (▲) and PCF9 (■). Results are expressed as the mean ± SD of triplicate determinations. The absorbance of the maximal cell growth (without Ab) and the background (without factors) was 1.06 ± 0.05 and 0.47 ± 0.01, respectively.
Tahara, T., Kuwaki, T., Matsumoto, A., Morita, H., Watarai, H., Inagaki, Y., ... & Kato, T. (1998). Neutralization of biological activity and inhibition of receptor binding by antibodies against human thrombopoietin. Stem Cells, 16(1), 54-60.
Figure 2 Serum TPO levels and circulating platelet counts after myelosuppressive chemotherapy.
Three patients with acute myeloid leukemia in complete remission were treated with myelosuppressive chemotherapy. Serum TPO levels were measured by a sensitive ELISA (closed circles), and platelet counts were measured by an automated blood cell counter (open circles). The open triangles show the time of platelet transfusion (10 units). The arrows (↓) show the time of measurement of serum TPO levels and platelet counts just before and 1 h after platelet transfusion. (a) The first course of consolidation chemotherapy in patient 1 (course I). (b) The second course of consolidation chemotherapy in patient 1 (course II). (c) The third course of consolidation chemotherapy in patient 1 (course III). (d) The first course of maintenance/intensification chemotherapy in patient 2. (e) The first course of consolidation chemotherapy in patient 3.
Shinjo, K., Takeshita, A., Nakamura, S., Naitoh, K., Yanagi, M., Tobita, T., ... & Ohno, R. (1998). Serum thrombopoietin levels in patients correlate inversely with platelet counts during chemotherapy-induced thrombocytopenia. Leukemia, 12(3), 295.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-973 | Recombinant Anti-human THPO Antibody | WB, IF, FuncS | IgG |
MHH-973 | Recombinant Human Anti-human THPO Antibody | ELISA, IP, FuncS | IgG |
MOB-0207MC | Anti-Dog (Canine) Thrombopoietin Antibody | WB | |
MOB-0208MC | Mouse Anti-THPO Recombinant Antibody (clone YC167) | WB, ICC, IHC-P, IHC-F, ELISA | Mouse IgG |
VS3-XY1514 | Mouse Anti-THPO Recombinant Antibody (clone 1B11) | ELISA, WB, FC | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-973-F(E) | Recombinant Anti-human THPO Antibody Fab Fragment | IF, FC, FuncS | Fab |
MHH-973-F(E) | Recombinant Human Anti-human THPO Antibody Fab Fragment | ELISA, WB, FuncS | Fab |
PFBZ-075 | Mouse Anti-THPO Recombinant Antibody (clone TN1); Fab Fragment | Neut, ELISA | Mouse Fab |
PFBW-122 | Human Anti-THPO Recombinant Antibody (clone TN1); Fab Fragment | Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-973-S(P) | Recombinant Anti-human THPO Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
MHH-973-S(P) | Recombinant Human Anti-human THPO Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
PSBZ-075 | Mouse Anti-THPO Recombinant Antibody (clone TN1); scFv Fragment | Neut, ELISA | Mouse scFv |
PSBW-122 | Human Anti-THPO Recombinant Antibody (clone TN1); scFv Fragment | Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-178 | Recombinant Mouse Anti-Thrombopoietin Antibody (TN1) | WB, Neut, FuncS | IgG |
PABX-178-S (P) | Recombinant Mouse Anti-Thrombopoietin Antibody scFv Fragment (TN1) | WB, Neut, FuncS | scFv |
PABX-178-F (E) | Recombinant Mouse Anti-Thrombopoietin Antibody Fab Fragment (TN1 ) | WB, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3566 | Rabbit Anti-Thpo Recombinant Antibody (clone DS3566AB) | ELISA | Rabbit IgG |
MOR-4456 | Rabbit Anti-THPO Recombinant Antibody (clone SI549DS) | ELISA | Rabbit IgG |
There are currently no Customer reviews or questions for PABZ-075. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.