Products

Anti-histone Immunocytokine, dI-IgG-ala (NHS76)-IL2 (D20T) (ACFP-SH115)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-histone dI-IgG-ala to IL2 (D20T). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the histone as well as the biological activity of IL2 (D20T). In NHS76-IL2, a mutation that eliminates a potential T-cell epitope in the variable region of the light chain was introduced. IL-2 derivative carrying a mutation at position 20 (D20T) was used, which exhibits a lower toxicity due to reduced activation of the intermediate-affinity IL-2 receptor. This immunocytokine was designed for treating necrotic tumor.      

Specifications
Target
Histone
Molecule Class
dI-IgG2-ala-IL2 (D20T)
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
NHS76
Related Disease
Necrotic tumor
Cytokines 1
IL2 (D20T)
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
Histones; histone HI; histone H3; histone H2B; histone H4; histone H2A

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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