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Anti-human MHC1 Intrabody [Tat] (IAB-B035(T))

Recombinant anti-human MHC1 intrabody in fusion with HIV Tat works within cells to bind human MHC1, expressed in 293T cells. The anti-human MHCI intrabody was used to transduce primary human keratinocytes, a marked reduction of surface MHCI expression was observed.      

Specifications
Immunogen
human major histocompatibility complex class I
Host
murine
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
human
Applications
Used for immunoassay techniques such as: Protein fragment complementation; Western blot; Functional studies
Target
Alternative Names
hMHC1; major histocompatibility complex class I

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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