Products

Anti-mesothelin Immunocytokine, IL12-scFv (SS1) (ACFP-SH061)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-mesothelin scFv to the C terminus of the p35 subunit of IL12 through a short linker (GSADGG). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the mesothelin as well as the biological activity of IL12. The immunocytokine retained sufficient bioactivity of IL12 and significantly inhibited human malignant mesothelioma (NCI-H226) grown in the peritoneal cavity of nude mice and showed comparable anti-tumor activity to that of the SS1P immunotoxin. This immunocytokine was designed for treating mesothelin-positive tumors.      

Specifications
Target
mesothelin
Molecule Class
IL12-scFv
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
SS1
Related Disease
Mesothelin-positive tumors
Cytokines 1
IL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
MSLN; mesothelin; MPF; SMRP; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor
Entrez Gene ID
10232
UniProt ID
Q13421

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved