This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-mesothelin scFv to the C terminus of the p35 subunit of IL12 through a short linker (GSADGG). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the mesothelin as well as the biological activity of IL12. The immunocytokine retained sufficient bioactivity of IL12 and significantly inhibited human malignant mesothelioma (NCI-H226) grown in the peritoneal cavity of nude mice and showed comparable anti-tumor activity to that of the SS1P immunotoxin. This immunocytokine was designed for treating mesothelin-positive tumors.
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CAT | Product Name | Application | Type |
---|---|---|---|
NABL-009 | Recombinant Anti-human MSLN VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
HPAB-M0391-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (NbA1/G3A) | ELISA, FC, IF | Llama VHH |
HPAB-M0392-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (NbC6/F10) | ELISA, FC, IF | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-201 | Anti-Human Mesothelin Recombinant Antibody (Amatuximab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G052E | Anti-MSLN immunotoxin RG7787 (Fab)-PE | Cytotoxicity assay, Function study | |
AGTO-G053E | Anti-Msln immunotoxin (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-L035E | anti-MSLN immunotoxin K1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L063E | anti-MSLN immunotoxin 8B35 (scFv)-PE | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0833CL | Human Anti-MSLN Recombinant Antibody (TAB-0833CL) | ELISA, FuncS, Activ, FC | Human IgG1 |
TAB-0834CL | Human Anti-MSLN Recombinant Antibody (TAB-0834CL) | ELISA, FuncS, FC, SPR, Inhib | Human IgG1, κ |
TAB-0833CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0833CL-F(E)) | ELISA, FC | Human Fab |
TAB-0834CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0834CL-F(E)) | ELISA, FC | Human Fab |
TAB-0835CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0835CL-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0376MZ | Chicken Anti-MSLN Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2302 | Hi-Affi™ Recombinant Rabbit Anti-MSLN Monoclonal Antibody (DS2302AB) | WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0646-CN | Human Anti-MSLN Recombinant Antibody (HPAB-0646-CN) | WB, ELISA, FC | Human IgG1 |
HPAB-M0155-YC | Human Anti-MSLN Recombinant Antibody (clone M/YC-16) | ELISA, WB | Chimeric (mouse/human) IgG |
HPAB-M0157-YC | Human Anti-MSLN Recombinant Antibody (HPAB-M0157-YC) | FuncS | Chimeric (rabbit/human) IgG |
HPAB-M0158-YC | Human Anti-MSLN Recombinant Antibody (HPAB-M0158-YC) | FuncS | Humanized IgG |
HPAB-M0159-YC | Human Anti-MSLN Recombinant Antibody (HPAB-M0159-YC) | FuncS | Chimeric (rabbit/human) IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0706-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0706-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
HPAB-0630-YJ-S(P) | Mouse Anti-MSLN Recombinant Antibody (clone K1); scFv Fragment | ELISA, IF | Mouse scFv |
HPAB-S0098-YC-S(P) | Mouse Anti-MSLN Recombinant Antibody (clone SS); scFv Fragment | ELISA | Mouse scFv |
FAMAB-0261WJ-S(P) | Human Anti-MSLN Recombinant Antibody (clone H1a059); scFv Fragment | ELISA, WB, FC | Human scFv |
FAMAB-0262WJ-S(P) | Human Anti-MSLN Recombinant Antibody (clone H1b011); scFv Fragment | ELISA, WB, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0861-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0861-CN-F(E)) | ELISA, FC, Neut | Human Fab |
HPAB-2427LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-2427LY-F(E)) | ELISA | Human Fab |
HPAB-2428LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-2428LY-F(E)) | ELISA | Human Fab |
HPAB-M0155-YC-F(E) | Human Anti-MSLN Recombinant Antibody (clone M/YC-16); Fab Fragment | ELISA, WB | Chimeric (mouse/human) Fab |
HPAB-M0157-YC-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-M0157-YC-F(E)) | FuncS | Chimeric (rabbit/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-201 | Afuco™ Anti-MSLN ADCC Recombinant Antibody (Amatuximab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0101 | APC-H-2Db/Human Mesothelin (GQKMNAQAI) MHC Tetramer | FCM | |
MHC-CN0102 | PE-H-2Db/Human Mesothelin (GQKMNAQAI) MHC Tetramer | FCM | |
MHC-CN1049 | PE-A*01:01/Human MSLN (TLDTLTAFY) MHC Tetramer | FCM, IHC | |
MHC-YF238 | A*02:01/Human Mesothelin (SLLFLLFSL) MHC Monomer | MHC Multimer | |
MHC-YF239 | A*02:01/Human Mesothelin (VLPLTVAEV) MHC Monomer | MHC Multimer |
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