Anti-αVβ3 Ectodomain antibody is a Mouse of scFv class that binds to an αVβ3 Ectodomain. This antibody is a primate-specific mouse mAb that inhibits V integrins, is in phase II trials for treating cancer.
Figure 1 17E6 perturbs M21 adhesion to vitronectin but not to other matrix components.
The inhibitory effect of 17E6 (αv, closed circles) and P4C10 (β1, open circles) on M21 cell attachment to vitronectin (A), laminin (B) or collagen type I (C) was studied. 17E6 only blocked cell attachment on vitronectin-coated surfaces. Whilst P4C10 only blocked cell attachment on collagen type I and laminin.
Mitjans, F., Sander, D., Adán, J., Sutter, A., Martinez, J. M., Jaggle, C. S., ... & Goodman, S. L. (1995). An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice. Journal of cell science, 108(8), 2825-2838.
Figure 2 Species-dependent inhibition of cell attachment by 17E6 and species-independent inhibition by cilengitide.
Representative cell adhesion inhibition assay comparing human melanoma cell line WM164 (circles), monkey cell line CV-1 (triangles), and rat cell line Rat-1 (boxes). Filled symbols show response to 17E6, and open symbols show response to the RGD-peptide cilengitide. Human and monkey cells are inhibited, and rat cells are not affected by 17E6. Each species is inhibited by cilengitide.
Mahalingam, B., Van Agthoven, J. F., Xiong, J. P., Alonso, J. L., Adair, B. D., Rui, X., ... & Goodman, S. L. (2014). Atomic basis for the species-specific inhibition of αV integrins by mAb 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex. Journal of Biological Chemistry, jbc-M113.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1133z | Mouse Anti-ITGAV Recombinant Antibody (clone 33D12) | ELISA, ICC, IF, IHC, IP, FuncS | Mouse IgG2a |
PABL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6) | WB, ELISA, FuncS | Mouse IgG |
MOB-0242CT | Recombinant Mouse anti-Human ITGAV Monoclonal antibody (24D3) | FC, IHC-Fr, PP | |
ZG-0041U | Rabbit Anti-ITGAV Recombinant Antibody (clone 5G3) | ELISA, WB, IHC | Rabbit IgG |
VS3-CJ455 | Rabbit Anti-ITGAV Recombinant Antibody (VS3-CJ455) | WB, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-076 | Anti-Human CD51 Recombinant Antibody (Intetumumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H01 | Anti-Human ITGAV Recombinant Antibody (Abituzumab) | Inhib, Agonist | IgG2 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
HPAB-1767-FY-F(E) | Human Anti-ITGAV Recombinant Antibody (clone 12G3); scFv Fragment | Cyt, ELISA | Humanized scFv |
HPAB-1768-FY-F(E) | Human Anti-ITGAV Recombinant Antibody (clone 3F2); scFv Fragment | Cyt, ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
HPAB-1767-FY-S(P) | Human Anti-ITGAV Recombinant Antibody (clone 12G3); Fab Fragment | Cyt, ELISA | Humanized Fab |
HPAB-1768-FY-S(P) | Human Anti-ITGAV Recombinant Antibody (clone 3F2); Fab Fragment | Cyt, ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-191-F (E) | Recombinant Mouse Anti-αVβ3 Ectodomain Antibody Fab Fragment (17E6) | Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1537CQ | Recombinant Mouse Anti-ITGAV Antibody (272-17E6) | Inhib, ICC/IF, BL, FC, ELISA, IP | IgG1 |
NEUT-1577CQ | Recombinant Mouse Anti-ITGAV Antibody (13C2) | FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion | IgG1, κ |
NEUT-1578CQ | Recombinant Mouse Anti-ITGAV Antibody (NKI-M9) | FC, IF, ELISA, BL, IP | IgG2a, κ |
NEUT-1580CQ | Recombinant Mouse Anti-ITGAV Antibody (27.1) | ICC/IF, FC, IP, IHC-Fr, BL | IgG1 |
NEUT-1581CQ | Recombinant Mouse Anti-ITGAV Antibody (P5H9) | CyTOF, BL, FC, IP, ICC | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1582CQ | Recombinant Rat Anti-Itgav Antibody (RMV-7) | FC, FuncS, IP, Neut | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1880 | Hi-Affi™ Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (DS1880AB) | WB, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-076 | Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Intetumumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-H01 | Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
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