This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-αvβ integrin receptor IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the αvβ integrin receptor as well as the biological activity of IL2. DI-17E6 can enhance the activity of cytotoxic drug based therapies, leading to more anti-tumor activity in vivo. DI-17E6 causes the depolymerization of focal adhesions dependent on αvβ3 and αvB5. These signalling complexes assemble after integrin ligation. They organize communication with growth, survival and motility pathways, and their destruction can trigger apoptosis. Thus DI-17E6 uses a combination of mechanochemical and biochemical effects to affect endothelia and to increase stress on tumor cells. This immunocytokine was designed for treating tumor.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1133z | Mouse Anti-ITGAV Recombinant Antibody (clone 33D12) | ELISA, ICC, IF, IHC, IP, FuncS | Mouse IgG2a |
MRO-0852-CN | Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (CBACN-313) | WB, FC | Rabbit IgG |
VS3-CJ455 | Rabbit Anti-ITGAV Recombinant Antibody (VS3-CJ455) | WB, FC | Rabbit IgG |
VS3-FY773 | Recombinant Rabbit Anti-ITGAV Antibody (clone R02-6G3) | WB, ICC, IF, IP | Rabbit IgG |
VS3-FY774 | Recombinant Rabbit Anti-ITGAV Antibody (clone R03-6E3) | WB, IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-076 | Anti-Human CD51 Recombinant Antibody (Intetumumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H01 | Anti-Human ITGAV Recombinant Antibody (Abituzumab) | Inhib, Agonist | IgG2 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
HPAB-1767-FY-F(E) | Human Anti-ITGAV Recombinant Antibody (clone 12G3); scFv Fragment | Cyt, ELISA | Humanized scFv |
HPAB-1768-FY-F(E) | Human Anti-ITGAV Recombinant Antibody (clone 3F2); scFv Fragment | Cyt, ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
HPAB-1767-FY-S(P) | Human Anti-ITGAV Recombinant Antibody (clone 12G3); Fab Fragment | Cyt, ELISA | Humanized Fab |
HPAB-1768-FY-S(P) | Human Anti-ITGAV Recombinant Antibody (clone 3F2); Fab Fragment | Cyt, ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-191-S (P) | Recombinant Mouse Anti-αVβ3 Ectodomain Antibody scFv Fragment (17E6) | Neut, FuncS | scFv |
PABX-191-F (E) | Recombinant Mouse Anti-αVβ3 Ectodomain Antibody Fab Fragment (17E6) | Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1537CQ | Recombinant Mouse Anti-ITGAV Antibody (272-17E6) | Inhib, ICC/IF, BL, FC, ELISA, IP | IgG1 |
NEUT-1577CQ | Recombinant Mouse Anti-ITGAV Antibody (13C2) | FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion | IgG1, κ |
NEUT-1578CQ | Recombinant Mouse Anti-ITGAV Antibody (NKI-M9) | FC, IF, ELISA, BL, IP | IgG2a, κ |
NEUT-1579CQ | Recombinant Mouse Anti-ITGAV Antibody (10D5) | IP, FC, BL | IgG2a |
NEUT-1580CQ | Recombinant Mouse Anti-ITGAV Antibody (27.1) | ICC/IF, FC, IP, IHC-Fr, BL | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1582CQ | Recombinant Rat Anti-Itgav Antibody (RMV-7) | FC, FuncS, IP, Neut | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1880 | Hi-Affi™ Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (DS1880AB) | WB, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-076 | Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Intetumumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-H01 | Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
There are currently no Customer reviews or questions for ACFP-SH136. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.