Anti-αvβ integrin receptor Antibody-Cytokine Fusion Protein, IgG (DI-17E6)-IL2 (CAT#: ACFP-SH136)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-αvβ integrin receptor IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the αvβ integrin receptor as well as the biological activity of IL2. DI-17E6 can enhance the activity of cytotoxic drug based therapies, leading to more anti-tumor activity in vivo. DI-17E6 causes the depolymerization of focal adhesions dependent on αvβ3 and αvB5. These signalling complexes assemble after integrin ligation. They organize communication with growth, survival and motility pathways, and their destruction can trigger apoptosis. Thus DI-17E6 uses a combination of mechanochemical and biochemical effects to affect endothelia and to increase stress on tumor cells. This immunocytokine was designed for treating tumor.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • αvβ integrin receptor
  • Molecule Class
  • L Kappa; IgG2-IL2
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • DI-17E6
  • Related Disease
  • Tumor
  • Cytokine 1
  • IL2
  • Cytokines 1 Description
  • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • CD51; MSK8; VNRA; VTNR

Downloads

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Human Antibody

CAT Product Name Application Type
TAB-076 Anti-Human CD51 Recombinant Antibody (Intetumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Humanized Antibody

CAT Product Name Application Type
TAB-H01 Anti-Human ITGAV Recombinant Antibody (Abituzumab) Inhib, Agonist IgG2 - kappa

Blocking Antibody

CAT Product Name Application Type
NEUT-1537CQ Recombinant Mouse Anti-ITGAV Antibody (272-17E6) Inhib, ICC/IF, BL, FC, ELISA, IP IgG1
NEUT-1577CQ Recombinant Mouse Anti-ITGAV Antibody (13C2) FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion IgG1, κ
NEUT-1578CQ Recombinant Mouse Anti-ITGAV Antibody (NKI-M9) FC, IF, ELISA, BL, IP IgG2a, κ
NEUT-1579CQ Recombinant Mouse Anti-ITGAV Antibody (10D5) IP, FC, BL IgG2a
NEUT-1580CQ Recombinant Mouse Anti-ITGAV Antibody (27.1) ICC/IF, FC, IP, IHC-Fr, BL IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1582CQ Recombinant Rat Anti-Itgav Antibody (RMV-7) FC, FuncS, IP, Neut IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-076 Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Intetumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-H01 Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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