Anti-CD19 (clone B496)-MCC-DM1 ADC (CAT#: ADC-182LZY)

This ADC product is composed of an anti-CD19 antibody (clone B496) conjugated via MCC linker to DM1 (B496-MCC-DM1). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Mouse Anti-CD19 IgG1, B496
  • Clone
  • B496
  • Antibody Isotype
  • IgG1
  • Linker
  • MCC (Maleimidomethyl cyclohexane-1-carboxylate)
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;

Related Resources

  • Related Diseases

Downloads

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Humanized Antibody

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TAB-H17 Anti-Human CD19 Recombinant Antibody (Denintuzumab Mafodotin) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-891 Humanized Anti-CD19 Recombinant Antibody (clone Denintuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Humanized IgG1, κ
TAB-1612CL Human Anti-CD19 Recombinant Antibody (TAB-1612CL) Depletion, FuncS Humanized IgG1
TAB-1625CL-F(E) Anti-Human CD19 Recombinant Antibody Fab Fragment (396) Depletion, ELISA Humanized antibody
TAB-431CQ Anti-Human CD19 Recombinant Antibody ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G076E Anti-CD19 immunotoxin HD37 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G076D Anti-CD19 immunotoxin HD37 (IgG)-DT Cytotoxicity assay, Function study
AGTO-G076R Anti-CD19 immunotoxin HD37 (IgG)-RTA Cytotoxicity assay, Function study
AGTO-G076S Anti-CD19 immunotoxin HD37 (IgG)-Sap Cytotoxicity assay, Function study
AGTO-G076P Anti-CD19 immunotoxin HD37 (IgG)-PAP Cytotoxicity assay, Function study

Low- or Non-fucosylated Oligosaccharide

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0100MZ Chicken Anti-CD19 Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-286CQ Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) Neut, FC, IHC, IHC-Fr, IP Mouse IgG1
NEUT-287CQ Mouse Anti-CD19 Recombinant Antibody (clone HIB19) FC, CyTOF, IHC, Block Mouse IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-288CQ Rat Anti-CD19 Recombinant Antibody (clone 1D3) Depletion, Block, FC Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0538 Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) IHC-P Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-174 Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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