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  • BV421-A*02:01/Human CALR (MLLSVPLLLG) MHC Tetramer

BV421-A*02:01/Human CALR (MLLSVPLLLG) MHC Tetramer (CAT#: MHC-LC1045)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of CALR-derived peptide of MLLSVPLLLG covering 1-10 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IHC staining of human duodenum
Figure 1 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19952/ihc_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to Endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79775/1900_C3_3_blue_red_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2242/8396_B_7_5.jpg
Figure 4 Thyroid gland
Figure 4 Thyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2242/8396_B_1_5.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000179218-CALR
Figure 5 RNA cell line category: Low cell line specificity
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000179218-CALR

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • CALR
  • Antigen Species
  • Human
  • Peptide
  • MLLSVPLLLG
  • Range
  • 1-10
  • Conjugate
  • BV421
  • Application
  • FCM

Target

  • Antigen Introduction
  • Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
  • Alternative Names
  • CALR; calreticulin; RO; CRT; SSA; cC1qR; HEL-S-99n

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See other products for "CALR"

Recombinant Antibody

CAT Product Name Application Type
MOB-1130z Mouse Anti-CALR Recombinant Antibody (clone 5H4) ELISA, IF, IHC, WB Mouse IgG2a
MOB-0287CT Mouse Anti-CALR Recombinant Antibody (clone EML269) IHC-P, WB Mouse IgG1
MRO-0219-CN Mouse Anti-CALR Recombinant Antibody (clone 7B1) WB, IHC, IF, FC Mouse IgG1
HPAB-0446-YJ Mouse Anti-CALR Recombinant Antibody (clone FMMU-CRT-10) FC, WB, CLEIA, ELISA, IHC Mouse IgG1, κ
HPAB-0447-YJ Human Anti-CALR Recombinant Antibody (clone chFMMU-CRT-10) ELISA, WB, IHC, FC Chimeric (mouse/human) IgG1, κ

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0076MZ Chicken Anti-Calreticulin Polyclonal IgY IHC Chicken antibody
BRD-0772MZ Chicken Anti-Calreticulin Polyclonal IgY Blocking Assay (BLOCK) IHC (Paraffin) (IHC (P)) ICC (ICC) Flow Cytometry (Flow) IHC (IHC) Chicken antibody

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1043 PE-A*02:01/Human CALR (MLLSVPLLLG) MHC Tetramer FCM
MHC-LC1044 APC-A*02:01/Human CALR (MLLSVPLLLG) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0443 Hi-Affi™ Rabbit Anti-CALR Recombinant Antibody (clone DS443AB) WB, IHC, ICC Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0271-YC-S(P) Mouse Anti-CALR Recombinant Antibody (clone 8B2-H6-10.7); scFv Fragment FC, WB Mouse scFv
HPAB-0446-YJ-S(P) Mouse Anti-CALR Recombinant Antibody (clone FMMU-CRT-10); scFv Fragment ELISA, WB, IHC, FC Mouse scFv
HPAB-0447-YJ-S(P) Mouse Anti-CALR Recombinant Antibody (clone chFMMU-CRT-10); scFv Fragment ELISA, WB, IHC, FC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0271-YC-F(E) Mouse Anti-CALR Recombinant Antibody (clone 8B2-H6-10.7); Fab Fragment FC, WB Mouse Fab
HPAB-0446-YJ-F(E) Mouse Anti-CALR Recombinant Antibody (clone FMMU-CRT-10); Fab Fragment ELISA, WB, IHC, FC Mouse Fab
HPAB-0447-YJ-F(E) Human Anti-CALR Recombinant Antibody (clone chFMMU-CRT-10); Fab Fragment ELISA, WB, IHC, FC Chimeric (mouse/human) Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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