Products

Becaplermin (TP-061CL)

Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds.      

Specifications
Classify
Protein therapeutics augmenting an existing pathway: Growth regulation
Therapeutic
Becaplermin (platelet-derived growth factor; PDGF)
Trade Name
Regranex
Function
Promotes wound healing by enhancing granulation tissue formation and fibroblast proliferation and differentiation
Examples of Clinical Use
Debridement adjunct for diabetic ulcers
References
Synonyms
c-sis, PDGF B-chain, PDGF-2, PDGF-BB, PDGFB, Platelet-derived growth factor B chain precursor, Platelet-derived growth factor beta polypeptide, SH-POLYPEPTIDE-59
UniProt
P01127
Genbank
K01401

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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