Becaplermin (CAT#: TP-061CL)
Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds.
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/1592_D1_1_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/1592_D1_1_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in granular pattern in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/ihc_selected.jpg
(Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in granular pattern in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/ihc_selected.jpg
Figure 3 Placenta
(Cytotrophoblasts Staining: Medium Intensity: Moderate Quantity:>75% Endothelial cells Staining: High Intensity: Strong Quantity:>75% Hofbauer cells Staining: Medium Intensity: Moderate Quantity:>75% Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_1_7.jpg
(Cytotrophoblasts Staining: Medium Intensity: Moderate Quantity:>75% Endothelial cells Staining: High Intensity: Strong Quantity:>75% Hofbauer cells Staining: Medium Intensity: Moderate Quantity:>75% Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_1_7.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_9_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_9_8.jpg
Figure 5 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_9_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_9_4.jpg
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_8_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11972/28202_A_8_5.jpg
Figure 7 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18341/40769_A_5_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18341/40769_A_5_6.jpg
Figure 8 RNA cell line category: Cell line enhanced (A-431, EFO-21, HUVEC TERT2, SK-BR-3, TIME)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000100311-PDGFB
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000100311-PDGFB
Specifications
- Classify
- Protein therapeutics augmenting an existing pathway: Growth regulation
- Therapeutic
- Becaplermin (platelet-derived growth factor; PDGF)
- Trade Name
- Regranex
- Function
- Promotes wound healing by enhancing granulation tissue formation and fibroblast proliferation and differentiation
- Examples of clinical use
- Debridement adjunct for diabetic ulcers
References
- Synonyms
- c-sis, PDGF B-chain, PDGF-2, PDGF-BB, PDGFB, Platelet-derived growth factor B chain precursor, Platelet-derived growth factor beta polypeptide, SH-POLYPEPTIDE-59
- UniProt
- P01127
- Genbank
- K01401
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "PDGFB"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-297 | Human Anti-PDGFB Recombinant Antibody (clone MOR8457) | WB, ELISA, FuncS | Human IgG1 |
| HPAB-0385-CN | Human Anti-PDGFB Recombinant Antibody (HPAB-0385-CN) | ELISA, FC, IF, Block | Human IgG |
| HPAB-0386-CN | Rat Anti-PDGFB Recombinant Antibody (HPAB-0386-CN) | ELISA, Block | Rat IgG2b, κ |
| FAMAB-0652WJ | Human Anti-PDGFB Recombinant Antibody (clone AB-001) | ELISA, WB | Human IgG1 |
| VS3-FY1113 | Recombinant Rabbit Anti-PDGFB Antibody (clone R06-7H6) | WB, IHC-P | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-297 | Human Anti-PDGFB Recombinant Antibody (clone MOR8457); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0385-CN-S(P) | Human Anti-PDGFB Recombinant Antibody; scFv Fragment (HPAB-0385-CN-S(P)) | ELISA, FC, IF, Block | Human scFv |
| HPAB-0386-CN-S(P) | Rat Anti-PDGFB Recombinant Antibody; scFv Fragment (HPAB-0386-CN-S(P)) | ELISA, Block | Rat scFv |
| HPAB-N0226-YC-S(P) | Mouse Anti-PDGFB Recombinant Antibody (clone NOV012YC); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0067-YJ-S(P) | Mouse Anti-PDGFB Recombinant Antibody (clone C1); scFv Fragment | ELISA, FuncS, Apop | Mouse scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1020CL | Anti-Human PDGFB Recombinant Antibody (F3) | ELISA | Rabbit mAb |
| TAB-1020CL-S(P) | Anti-Human PDGFB Recombinant Antibody scFv Fragment (F3) | ELISA | Rabbit mAb |
| TAB-1020CL-F(E) | Anti-Human PDGFB Recombinant Antibody Fab Fragment (F3) | ELISA | Rabbit mAb |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1021CL | Anti-Human PDGFB Recombinant Antibody (C12) | ELISA | Humanized antibody |
| TAB-1021CL-S(P) | Anti-Human PDGFB Recombinant Antibody scFv Fragment (C12) | ELISA | Humanized antibody |
| TAB-1021CL-F(E) | Anti-Human PDGFB Recombinant Antibody Fab Fragment (C12) | ELISA | Humanized antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2635 | Hi-Affi™ Recombinant Rabbit Anti-PDGFB Monoclonal Antibody (DS2635AB) | WB, IHC-P | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0385-CN-F(E) | Human Anti-PDGFB Recombinant Antibody; Fab Fragment (HPAB-0385-CN-F(E)) | ELISA, FC, IF, Block | Human Fab |
| HPAB-0386-CN-F(E) | Rat Anti-PDGFB Recombinant Antibody; Fab Fragment (HPAB-0386-CN-F(E)) | ELISA, Block | Rat Fab |
| HPAB-0387-CN-F(E) | Rat Anti-PDGFB Recombinant Antibody; Fab Fragment (HPAB-0387-CN-F(E)) | ELISA, Block | Rat Fab |
| HPAB-0388-CN-F(E) | Rat Anti-PDGFB Recombinant Antibody; Fab Fragment (HPAB-0388-CN-F(E)) | ELISA, Block | Rat Fab |
| HPAB-0389-CN-F(E) | Human Anti-PDGFB Recombinant Antibody; Fab Fragment (HPAB-0389-CN-F(E)) | ELISA, Block | Humanized Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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