Products

Anti-Ang2 × Anti-VEGFA Bispecific Antibody (TAND-L042)

Recombinant Anti-Ang2 × Anti-VEGFA Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains, are smaller than whole IgGs or IgG-derived bsAbs, but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of blocking two proangiogenics simultaneously and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of Age Related Macular Degeneration.      

Specifications
Targets
Ang2 & VEGFA
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
Ang2
Host
Mouse
Target 2
VEGFA
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Age Related Macular Degeneration
Targets
Target 1
Ang2
Gene ID
285
UniProt ID
O15123
Alternative Names
ANGPT2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B
Target 2
VEGFA
Gene ID
7422
UniProt ID
P15692
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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