Products

Anti-CD18 × Anti-C3d Bispecific Antibody (BSIG-L001)

Anti-CD18 × Anti-C3d Bispecific Antibody (IgG-IgG) is a chemical conjugate composed of the anti-CD18 monoclonal antibody and the other antibody specific for C3d. A stable thioether linkage is formed between the two antibodies. This BsAb can reverse the consequences of opsonin-receptor mismatch by permitting interactions between PMN phagocytosis receptors and C3b or a bacteria antigen, thereby enhancing the phagocytosis and killing of bacteria. It was designed for the treatment of bacterial infection in the lungs of cystic fibrosis (CF).      

Specifications
Targets
CD18 & C3d
Type
IgG-IgG
Species Reactivity
Human
Target 1
CD18
Host
Mouse
Clone
60.3
Target 2
C3d
Host
Pseudomonas aeruginosa
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Cystic fibrosis (CF)
Targets
Target 1
CD18
Gene ID
3689
UniProt ID
P05107
Alternative Names
ITGB2; integrin, beta 2; complement component 3 receptor 3 and 4 subunit; LAD; CD18; MF17; MFI7; LCAMB
Target 2
C3d
Gene ID
718
UniProt ID
P01024
Alternative Names
ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved