Products

Anti-CD20 × Anti-CD22 Bispecific Antibody (TAND-L039)

Recombinant Anti-CD20 × Anti-CD22 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to one cell surface antigens and the other two to the other cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This bispecific antibody can induce apoptosis and growth inhibition without second-antibody crosslinking, and is significantly more potent in killing lymphoma cells. It was designed for the treatment of B-cell lymphomas or leukemias, autoimmune disease, immune dysfunction disease.      

Specifications
Targets
CD20 & CD22
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
CD20
Host
Human
Clone
1F5
Target 2
CD22
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
B-cell lymphomas, Leukemias, Autoimmune disease, Immune dysfunction disease
Targets
Target 1
CD20
Gene ID
931
UniProt ID
A0A024R507
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2
Target 2
CD22
Gene ID
933
UniProt ID
P20273
Alternative Names
CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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