Recombinant Anti-CD20 × Anti-CD22 Bispecific Antibody (Tandem Diabody) (CAT#: TAND-L039)
Recombinant Anti-CD20 × Anti-CD22 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to one cell surface antigens and the other two to the other cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This bispecific antibody can induce apoptosis and growth inhibition without second-antibody crosslinking, and is significantly more potent in killing lymphoma cells. It was designed for the treatment of B-cell lymphomas or leukemias, autoimmune disease, immune dysfunction disease.
Specific Inquiry
Specifications
- Target
- CD20 & CD22
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- CD20
- Host Species 1
- Human
- Target 2
- CD22
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- B-cell lymphomas, Leukemias, Autoimmune disease, Immune dysfunction disease
Target
- Target 1
- CD20
- Gene ID
- 931
- UniProt ID
- A0A024R507
- Alternative Names
- MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
- Target 2
- CD22
- Gene ID
- 933
- UniProt ID
- P20273
- Alternative Names
- CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2
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CrossMab
| CAT | Product Name | Application | Type |
|---|---|---|---|
| CROSS-L023 | Recombinant Anti-CD20 × Anti-CD22 Bispecific Antibody (CrossMab) | FuncS, Promising therapeutic agent | CrossMab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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